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Open AccessArticle

Influence of Hydroxyapatite Surface Functionalization on Thermal and Biological Properties of Poly(l-Lactide)- and Poly(l-Lactide-co-Glycolide)-Based Composites

1
Department of Engineering and Technology of Polymers, Faculty of Chemistry, Wrocław University of Science and Technology, Wyb. Wyspiańskiego 27, 50-370 Wrocław, Poland
2
Department of Mechanics, Materials and Biomedical Engineering, Faculty of Mechanical Engineering, Wroclaw University of Science and Technology, Wyb. Wyspiańskiego 27, 50-370 Wrocław, Poland
3
Department of Immunology and Infectious Biology, Faculty of Biology and Environmental Protection, University of Łódz, Banacha 12/16, 90-237 Łódź, Poland
4
Laser and Fibre Electronics Group, Faculty of Electronics, Wrocław University of Science and Technology, Wyb. Wyspiańskiego 27, 50-370 Wrocław, Poland
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(18), 6711; https://doi.org/10.3390/ijms21186711
Received: 31 July 2020 / Revised: 4 September 2020 / Accepted: 10 September 2020 / Published: 13 September 2020
(This article belongs to the Special Issue Polymeric Scaffolds: Design, Processing, and Biomedical Application)
Novel biocomposites of poly(L-lactide) (PLLA) and poly(l-lactide-co-glycolide) (PLLGA) with 10 wt.% of surface-modified hydroxyapatite particles, designed for applications in bone tissue engineering, are presented in this paper. The surface of hydroxyapatite (HAP) was modified with polyethylene glycol by using l-lysine as a linker molecule. The modification strategy fulfilled two important goals: improvement of the adhesion between the HAP surface and PLLA and PLLGA matrices, and enhancement of the osteological bioactivity of the composites. The surface modifications of HAP were confirmed by attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR), TGA, and elemental composition analysis. The influence of hydroxyapatite surface functionalization on the thermal and in vitro biological properties of PLLA- and PLLGA-based composites was investigated. Due to HAP modification with polyethylene glycol, the glass transition temperature of PLLA was reduced by about 24.5 °C, and melt and cold crystallization abilities were significantly improved. These achievements were scored based on respective shifting of onset of melt and cold crystallization temperatures and 1.6 times higher melt crystallization enthalpy compared with neat PLLA. The results showed that the surface-modified HAP particles were multifunctional and can act as nucleating agents, plasticizers, and bioactive moieties. Moreover, due to the presented surface modification of HAP, the crystallinity degree of PLLA and PLLGA and the polymorphic form of PLLA, the most important factors affecting mechanical properties and degradation behaviors, can be controlled. View Full-Text
Keywords: biocomposites; hydroxyapatite surface biofunctionalization; l-lysine; biosafety; monocytes biocomposites; hydroxyapatite surface biofunctionalization; l-lysine; biosafety; monocytes
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MDPI and ACS Style

Gazińska, M.; Krokos, A.; Kobielarz, M.; Włodarczyk, M.; Skibińska, P.; Stępak, B.; Antończak, A.; Morawiak, M.; Płociński, P.; Rudnicka, K. Influence of Hydroxyapatite Surface Functionalization on Thermal and Biological Properties of Poly(l-Lactide)- and Poly(l-Lactide-co-Glycolide)-Based Composites. Int. J. Mol. Sci. 2020, 21, 6711. https://doi.org/10.3390/ijms21186711

AMA Style

Gazińska M, Krokos A, Kobielarz M, Włodarczyk M, Skibińska P, Stępak B, Antończak A, Morawiak M, Płociński P, Rudnicka K. Influence of Hydroxyapatite Surface Functionalization on Thermal and Biological Properties of Poly(l-Lactide)- and Poly(l-Lactide-co-Glycolide)-Based Composites. International Journal of Molecular Sciences. 2020; 21(18):6711. https://doi.org/10.3390/ijms21186711

Chicago/Turabian Style

Gazińska, Małgorzata; Krokos, Anna; Kobielarz, Magdalena; Włodarczyk, Marcin; Skibińska, Paulina; Stępak, Bogusz; Antończak, Arkadiusz; Morawiak, Milena; Płociński, Przemysław; Rudnicka, Karolina. 2020. "Influence of Hydroxyapatite Surface Functionalization on Thermal and Biological Properties of Poly(l-Lactide)- and Poly(l-Lactide-co-Glycolide)-Based Composites" Int. J. Mol. Sci. 21, no. 18: 6711. https://doi.org/10.3390/ijms21186711

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