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Volume 21
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10.3390/ijms21176174
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Communication

“Clicking” an Ionic Liquid to a Potent Antimicrobial Peptide: On the Route towards Improved Stability

by
Ana Gomes
1,
Lucinda J. Bessa
1,
Patrícia Correia
1,
Iva Fernandes
1,
Ricardo Ferraz
1,2,
Paula Gameiro
1,
Cátia Teixeira
1 and
Paula Gomes
1,*
1
LAQV-REQUIMTE, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, P-4169-007 Porto, Portugal
2
Ciências Químicas e das Biomoléculas, Escola Superior de Saúde, Politécnico do Porto, P-4200-072 Porto, Portugal
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(17), 6174; https://doi.org/10.3390/ijms21176174
Submission received: 6 July 2020 / Revised: 7 August 2020 / Accepted: 17 August 2020 / Published: 26 August 2020
(This article belongs to the Collection Feature Papers in Molecular Pharmacology)
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Abstract

A covalent conjugate between an antibacterial ionic liquid and an antimicrobial peptide was produced via “click” chemistry, and found to retain the parent peptide’s activity against multidrug-resistant clinical isolates of Gram-negative bacteria, and antibiofilm action on a resistant clinical isolate of Klebsiella pneumoniae, while exhibiting much improved stability towards tyrosinase-mediated modifications. This unprecedented communication is a prelude for the promise held by ionic liquids -based approaches as tools to improve the action of bioactive peptides.
Keywords: antibacterial; antibiofilm; ionic liquid; multidrug resistance; peptide; skin infections; tyrosinase; wound healing antibacterial; antibiofilm; ionic liquid; multidrug resistance; peptide; skin infections; tyrosinase; wound healing
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MDPI and ACS Style

Gomes, A.; Bessa, L.J.; Correia, P.; Fernandes, I.; Ferraz, R.; Gameiro, P.; Teixeira, C.; Gomes, P. “Clicking” an Ionic Liquid to a Potent Antimicrobial Peptide: On the Route towards Improved Stability. Int. J. Mol. Sci. 2020, 21, 6174. https://doi.org/10.3390/ijms21176174

AMA Style

Gomes A, Bessa LJ, Correia P, Fernandes I, Ferraz R, Gameiro P, Teixeira C, Gomes P. “Clicking” an Ionic Liquid to a Potent Antimicrobial Peptide: On the Route towards Improved Stability. International Journal of Molecular Sciences. 2020; 21(17):6174. https://doi.org/10.3390/ijms21176174

Chicago/Turabian Style

Gomes, Ana, Lucinda J. Bessa, Patrícia Correia, Iva Fernandes, Ricardo Ferraz, Paula Gameiro, Cátia Teixeira, and Paula Gomes. 2020. "“Clicking” an Ionic Liquid to a Potent Antimicrobial Peptide: On the Route towards Improved Stability" International Journal of Molecular Sciences 21, no. 17: 6174. https://doi.org/10.3390/ijms21176174

APA Style

Gomes, A., Bessa, L. J., Correia, P., Fernandes, I., Ferraz, R., Gameiro, P., Teixeira, C., & Gomes, P. (2020). “Clicking” an Ionic Liquid to a Potent Antimicrobial Peptide: On the Route towards Improved Stability. International Journal of Molecular Sciences, 21(17), 6174. https://doi.org/10.3390/ijms21176174

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