Next Article in Journal
Interplay between Peripheral and Central Inflammation in Obesity-Promoted Disorders: The Impact on Synaptic Mitochondrial Functions
Next Article in Special Issue
The Effect of Dysfunctional Ubiquitin Enzymes in the Pathogenesis of Most Common Diseases
Previous Article in Journal
eATP/P2X7R Axis: An Orchestrated Pathway Triggering Inflammasome Activation in Muscle Diseases
Previous Article in Special Issue
Role of the Ubiquitin Proteasome System in the Regulation of Blood Pressure: A Review
Open AccessReview

Targeting E3 Ubiquitin Ligases and Deubiquitinases in Ciliopathy and Cancer

1
Department of Integrative Pharmacology, Graduate School of Medicine, Mie University, Tsu, Mie 514-8507, Japan
2
Department of Physiology, Graduate School of Medicine, Mie University, Tsu, Mie 514-5807, Japan
3
Gene Regulation Research, Division of Biological Sciences, Nara Institute of Science and Technology, Takayama, Nara 630-0192, Japan
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(17), 5962; https://doi.org/10.3390/ijms21175962
Received: 31 July 2020 / Revised: 16 August 2020 / Accepted: 17 August 2020 / Published: 19 August 2020
(This article belongs to the Special Issue Ubiquitination in Health and Diseases)
Cilia are antenna-like structures present in many vertebrate cells. These organelles detect extracellular cues, transduce signals into the cell, and play an essential role in ensuring correct cell proliferation, migration, and differentiation in a spatiotemporal manner. Not surprisingly, dysregulation of cilia can cause various diseases, including cancer and ciliopathies, which are complex disorders caused by mutations in genes regulating ciliary function. The structure and function of cilia are dynamically regulated through various mechanisms, among which E3 ubiquitin ligases and deubiquitinases play crucial roles. These enzymes regulate the degradation and stabilization of ciliary proteins through the ubiquitin–proteasome system. In this review, we briefly highlight the role of cilia in ciliopathy and cancer; describe the roles of E3 ubiquitin ligases and deubiquitinases in ciliogenesis, ciliopathy, and cancer; and highlight some of the E3 ubiquitin ligases and deubiquitinases that are potential therapeutic targets for these disorders. View Full-Text
Keywords: ubiquitin–proteasome pathway; cilia; ciliogenesis; differentiation; proliferation; ciliopathy; cancer ubiquitin–proteasome pathway; cilia; ciliogenesis; differentiation; proliferation; ciliopathy; cancer
Show Figures

Figure 1

MDPI and ACS Style

Shiromizu, T.; Yuge, M.; Kasahara, K.; Yamakawa, D.; Matsui, T.; Bessho, Y.; Inagaki, M.; Nishimura, Y. Targeting E3 Ubiquitin Ligases and Deubiquitinases in Ciliopathy and Cancer. Int. J. Mol. Sci. 2020, 21, 5962.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop