Next Article in Journal
Potential Mechanisms of Bisphenol A (BPA) Contributing to Human Disease
Next Article in Special Issue
Estrogen Induces Selective Transcription of Caveolin1 Variants in Human Breast Cancer through Estrogen Responsive Element-Dependent Mechanisms
Previous Article in Journal
Comparative Transcriptomics of Rice Genotypes with Contrasting Responses to Nitrogen Stress Reveals Genes Influencing Nitrogen Uptake through the Regulation of Root Architecture
Previous Article in Special Issue
Global View of Candidate Therapeutic Target Genes in Hormone-Responsive Breast Cancer
Review

The Importance of Breast Adipose Tissue in Breast Cancer

1
Department of Molecular Medicine, Faculty of Medicine, Laval University, Quebec, QC G1T 1C2, Canada
2
Cancer Research Centre, CHU de Quebec Research Centre, Quebec, QC G1V 4G2, Canada
3
Department of Preventive and Social Medicine, Faculty of Medicine, Laval University, Quebec, QC G1T 1C2, Canada
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(16), 5760; https://doi.org/10.3390/ijms21165760
Received: 22 June 2020 / Revised: 31 July 2020 / Accepted: 6 August 2020 / Published: 11 August 2020
Adipose tissue is a complex endocrine organ, with a role in obesity and cancer. Adipose tissue is generally linked to excessive body fat, and it is well known that the female breast is rich in adipose tissue. Hence, one can wonder: what is the role of adipose tissue in the breast and why is it required? Adipose tissue as an organ consists of adipocytes, an extracellular matrix (ECM) and immune cells, with a significant role in the dynamics of breast changes throughout the life span of a female breast from puberty, pregnancy, lactation and involution. In this review, we will discuss the importance of breast adipose tissue in breast development and its involvement in breast changes happening during pregnancy, lactation and involution. We will focus on understanding the biology of breast adipose tissue, with an overview on its involvement in the various steps of breast cancer development and progression. The interaction between the breast adipose tissue surrounding cancer cells and vice-versa modifies the tumor microenvironment in favor of cancer. Understanding this mutual interaction and the role of breast adipose tissue in the tumor microenvironment could potentially raise the possibility of overcoming breast adipose tissue mediated resistance to therapies and finding novel candidates to target breast cancer. View Full-Text
Keywords: breast development; breast cancer; breast adipose tissue; risk factors; therapeutic intervention breast development; breast cancer; breast adipose tissue; risk factors; therapeutic intervention
Show Figures

Figure 1

MDPI and ACS Style

Kothari, C.; Diorio, C.; Durocher, F. The Importance of Breast Adipose Tissue in Breast Cancer. Int. J. Mol. Sci. 2020, 21, 5760. https://doi.org/10.3390/ijms21165760

AMA Style

Kothari C, Diorio C, Durocher F. The Importance of Breast Adipose Tissue in Breast Cancer. International Journal of Molecular Sciences. 2020; 21(16):5760. https://doi.org/10.3390/ijms21165760

Chicago/Turabian Style

Kothari, Charu, Caroline Diorio, and Francine Durocher. 2020. "The Importance of Breast Adipose Tissue in Breast Cancer" International Journal of Molecular Sciences 21, no. 16: 5760. https://doi.org/10.3390/ijms21165760

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop