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Review
Peer-Review Record

The Role of Pre-Clinical 3-Dimensional Models of Osteosarcoma

Int. J. Mol. Sci. 2020, 21(15), 5499; https://doi.org/10.3390/ijms21155499
by Hannah L. Smith 1,2, Stephen A. Beers 1, Juliet C. Gray 1 and Janos M. Kanczler 2,*
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Int. J. Mol. Sci. 2020, 21(15), 5499; https://doi.org/10.3390/ijms21155499
Submission received: 7 July 2020 / Revised: 29 July 2020 / Accepted: 30 July 2020 / Published: 31 July 2020
(This article belongs to the Section Molecular Oncology)

Round 1

Reviewer 1 Report

In the manuscript “The role of pre-clinical 3-Dimensional models of osteosarcoma” the authors describe the actual models used for the development of osteosarcoma both in vitro and in vivo, showing both the advantages and the limitations of all of them.

The review is well written, practical and concise. It is relevant for researcher and clinicians as well.

Just few minor revisions:

Please levels out the words” in vitro and in vivo “in the text (in the manuscript is always reported “in vitro” while in the conclusion paragraph is written “in vitro)

Phrase 257: modify the sentence “here I suggest”  

Author Response

Please see attachment

Author Response File: Author Response.pdf

Reviewer 2 Report

The review provides a comprehensive and well documented revision of the 3-D models developed for osteosarcoma.

Points to be addressed.

_the abbreviated form OS should be used Throughout the manuscript

-The most relevant achievments obtained by the use of the different models should be reported and discussed with particular attention to any potential discrepancies observed.

Author Response

Please see attachment

Author Response File: Author Response.pdf

Round 2

Reviewer 2 Report

The manuscript has been improved adequately and it is now acceptable for publication.

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