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Review

ALIAmides Update: Palmitoylethanolamide and Its Formulations on Management of Peripheral Neuropathic Pain

1
Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D’Alcontres 31, 98166 Messina, Italy
2
Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, 1402 South Grand Blvd, St Louis, MO 63104, USA
*
Author to whom correspondence should be addressed.
The authors contributed equally to the work.
Int. J. Mol. Sci. 2020, 21(15), 5330; https://doi.org/10.3390/ijms21155330
Received: 8 July 2020 / Revised: 23 July 2020 / Accepted: 24 July 2020 / Published: 27 July 2020
(This article belongs to the Special Issue Amides)
Neuropathic pain results from lesions or diseases of the somatosensory nervous system and it remains largely difficult to treat. Peripheral neuropathic pain originates from injury to the peripheral nervous system (PNS) and manifests as a series of symptoms and complications, including allodynia and hyperalgesia. The aim of this review is to discuss a novel approach on neuropathic pain management, which is based on the knowledge of processes that underlie the development of peripheral neuropathic pain; in particular highlights the role of glia and mast cells in pain and neuroinflammation. ALIAmides (autacoid local injury antagonist amides) represent a group of endogenous bioactive lipids, including palmitoylethanolamide (PEA), which play a central role in numerous biological processes, including pain, inflammation, and lipid metabolism. These compounds are emerging thanks to their anti-inflammatory and anti-hyperalgesic effects, due to the down-regulation of activation of mast cells. Collectively, preclinical and clinical studies support the idea that ALIAmides merit further consideration as therapeutic approach for controlling inflammatory responses, pain, and related peripheral neuropathic pain. View Full-Text
Keywords: peripheral neuropathic pain; neuroinflammation; ALIAmides; palmitoylethanolamide peripheral neuropathic pain; neuroinflammation; ALIAmides; palmitoylethanolamide
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MDPI and ACS Style

D’Amico, R.; Impellizzeri, D.; Cuzzocrea, S.; Di Paola, R. ALIAmides Update: Palmitoylethanolamide and Its Formulations on Management of Peripheral Neuropathic Pain. Int. J. Mol. Sci. 2020, 21, 5330. https://doi.org/10.3390/ijms21155330

AMA Style

D’Amico R, Impellizzeri D, Cuzzocrea S, Di Paola R. ALIAmides Update: Palmitoylethanolamide and Its Formulations on Management of Peripheral Neuropathic Pain. International Journal of Molecular Sciences. 2020; 21(15):5330. https://doi.org/10.3390/ijms21155330

Chicago/Turabian Style

D’Amico, Ramona, Daniela Impellizzeri, Salvatore Cuzzocrea, and Rosanna Di Paola. 2020. "ALIAmides Update: Palmitoylethanolamide and Its Formulations on Management of Peripheral Neuropathic Pain" International Journal of Molecular Sciences 21, no. 15: 5330. https://doi.org/10.3390/ijms21155330

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