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Immunotherapies and Combination Strategies for Immuno-Oncology

1
OMS Students, School of Osteopathic Medicine, Lake Erie College of Osteopathic Medicine (LECOM), 5000 Lakewood Ranch Blvd, Bradenton, FL 34211, USA
2
Department of Internal Medicine, Southern Illinois University, Springfield, IL 62702, USA
3
Department of Radiation Oncology, University of Maryland, School of Medicine, Baltimore, MD 21201, USA
4
Department of Biostatistics, University of Florida, Gainesville, FL 32611, USA
5
School of Dental Medicine, Lake Erie College of Osteopathic Medicine (LECOM), 4800 Lakewood Ranch Blvd, Bradenton, FL 34211, USA
6
School of Pharmacy, Lake Erie College of Osteopathic Medicine (LECOM), 5000 Lakewood Ranch Blvd, Bradenton, FL 34211, USA
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2020, 21(14), 5009; https://doi.org/10.3390/ijms21145009
Received: 14 May 2020 / Revised: 10 July 2020 / Accepted: 13 July 2020 / Published: 15 July 2020
(This article belongs to the Special Issue Monoclonal Antibodies to Treat Cancer)
The advent of novel immunotherapies in the treatment of cancers has dramatically changed the landscape of the oncology field. Recent developments in checkpoint inhibition therapies, tumor-infiltrating lymphocyte therapies, chimeric antigen receptor T cell therapies, and cancer vaccines have shown immense promise for significant advancements in cancer treatments. Immunotherapies act on distinct steps of immune response to augment the body’s natural ability to recognize, target, and destroy cancerous cells. Combination treatments with immunotherapies and other modalities intend to activate immune response, decrease immunosuppression, and target signaling and resistance pathways to offer a more durable, long-lasting treatment compared to traditional therapies and immunotherapies as monotherapies for cancers. This review aims to briefly describe the rationale, mechanisms of action, and clinical efficacy of common immunotherapies and highlight promising combination strategies currently approved or under clinical development. Additionally, we will discuss the benefits and limitations of these immunotherapy approaches as monotherapies as well as in combination with other treatments. View Full-Text
Keywords: checkpoint inhibition; immunotherapy; chemoresistance; combination therapy; radiation therapy; adoptive cell transfer; chemotherapy checkpoint inhibition; immunotherapy; chemoresistance; combination therapy; radiation therapy; adoptive cell transfer; chemotherapy
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MDPI and ACS Style

Barbari, C.; Fontaine, T.; Parajuli, P.; Lamichhane, N.; Jakubski, S.; Lamichhane, P.; Deshmukh, R.R. Immunotherapies and Combination Strategies for Immuno-Oncology. Int. J. Mol. Sci. 2020, 21, 5009. https://doi.org/10.3390/ijms21145009

AMA Style

Barbari C, Fontaine T, Parajuli P, Lamichhane N, Jakubski S, Lamichhane P, Deshmukh RR. Immunotherapies and Combination Strategies for Immuno-Oncology. International Journal of Molecular Sciences. 2020; 21(14):5009. https://doi.org/10.3390/ijms21145009

Chicago/Turabian Style

Barbari, Cody; Fontaine, Tyler; Parajuli, Priyanka; Lamichhane, Narottam; Jakubski, Silvia; Lamichhane, Purushottam; Deshmukh, Rahul R. 2020. "Immunotherapies and Combination Strategies for Immuno-Oncology" Int. J. Mol. Sci. 21, no. 14: 5009. https://doi.org/10.3390/ijms21145009

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