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Review

Egg Allergy: Diagnosis and Immunotherapy

NeuroAllergy Research Laboratory (NARL), School of Life and Environmental Sciences, Faculty of Science, Engineering and Built Environment, Deakin University, 75 Pigdons Road, Geelong 3216 VIC, Australia
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Int. J. Mol. Sci. 2020, 21(14), 5010; https://doi.org/10.3390/ijms21145010
Received: 1 May 2020 / Revised: 3 July 2020 / Accepted: 14 July 2020 / Published: 16 July 2020
(This article belongs to the Special Issue Molecular and Cellular Basis of Food Allergies)
Hypersensitivity or an allergy to chicken egg proteins is a predominant symptomatic condition affecting 1 in 20 children in Australia; however, an effective form of therapy has not yet been found. This occurs as the immune system of the allergic individual overreacts when in contact with egg allergens (egg proteins), triggering a complex immune response. The subsequent instantaneous inflammatory immune response is characterized by the excessive production of immunoglobulin E (IgE) antibody against the allergen, T-cell mediators and inflammation. Current allergen-specific approaches to egg allergy diagnosis and treatment lack consistency and therefore pose safety concerns among anaphylactic patients. Immunotherapy has thus far been found to be the most efficient way to treat and relieve symptoms, this includes oral immunotherapy (OIT) and sublingual immunotherapy (SLIT). A major limitation in immunotherapy, however, is the difficulty in preparing effective and safe extracts from natural allergen sources. Advances in molecular techniques allow for the production of safe and standardized recombinant and hypoallergenic egg variants by targeting the IgE-binding epitopes responsible for clinical allergic symptoms. Site-directed mutagenesis can be performed to create such safe hypoallergens for their potential use in future methods of immunotherapy, providing a feasible standardized therapeutic approach to target egg allergies safely. View Full-Text
Keywords: hypersensitivity; recombinant allergens; immunotherapy; hypoallergens; egg allergy; allergy; egg allergens hypersensitivity; recombinant allergens; immunotherapy; hypoallergens; egg allergy; allergy; egg allergens
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MDPI and ACS Style

Dona, D.W.; Suphioglu, C. Egg Allergy: Diagnosis and Immunotherapy. Int. J. Mol. Sci. 2020, 21, 5010. https://doi.org/10.3390/ijms21145010

AMA Style

Dona DW, Suphioglu C. Egg Allergy: Diagnosis and Immunotherapy. International Journal of Molecular Sciences. 2020; 21(14):5010. https://doi.org/10.3390/ijms21145010

Chicago/Turabian Style

Dona, Dulashi W., and Cenk Suphioglu. 2020. "Egg Allergy: Diagnosis and Immunotherapy" International Journal of Molecular Sciences 21, no. 14: 5010. https://doi.org/10.3390/ijms21145010

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