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Can Physical Activity Support the Endocannabinoid System in the Preventive and Therapeutic Approach to Neurological Disorders?

Department of Physiology, Medical University of Bialystok, 15-089 Białystok, Poland
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Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(12), 4221; https://doi.org/10.3390/ijms21124221
Received: 20 May 2020 / Revised: 7 June 2020 / Accepted: 9 June 2020 / Published: 13 June 2020
(This article belongs to the Section Molecular Neurobiology)
The worldwide prevalence of neurological and neurodegenerative disorders, such as depression or Alzheimer’s disease, has spread extensively throughout the last decades, becoming an enormous health issue. Numerous data indicate a distinct correlation between the altered endocannabinoid signaling and different aspects of brain physiology, such as memory or neurogenesis. Moreover, the endocannabinoid system is widely regarded as a crucial factor in the development of neuropathologies. Thus, targeting those disorders via synthetic cannabinoids, as well as phytocannabinoids, becomes a widespread research issue. Over the last decade, the endocannabinoid system has been extensively studied for its correlation with physical activity. Recent data showed that physical activity correlates with elevated endocannabinoid serum concentrations and increased cannabinoid receptor type 1 (CB1R) expression in the brain, which results in positive neurological effects including antidepressant effect, ameliorated memory, neuroplasticity development, and reduced neuroinflammation. However, none of the prior reviews presented a comprehensive correlation between physical activity, the endocannabinoid system, and neuropathologies. Thus, our review provides a current state of knowledge of the endocannabinoid system, its action in physical activity, as well as neuropathologies and a possible correlation between all those fields. We believe that this might contribute to finding a new preventive and therapeutic approach to both neurological and neurodegenerative disorders. View Full-Text
Keywords: endocannabinoid system; ECS; cannabinoids; phytocannabinoids; physical activity; neurological disorders; neurodegenerative disorders endocannabinoid system; ECS; cannabinoids; phytocannabinoids; physical activity; neurological disorders; neurodegenerative disorders
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MDPI and ACS Style

Charytoniuk, T.; Zywno, H.; Konstantynowicz-Nowicka, K.; Berk, K.; Bzdega, W.; Chabowski, A. Can Physical Activity Support the Endocannabinoid System in the Preventive and Therapeutic Approach to Neurological Disorders? Int. J. Mol. Sci. 2020, 21, 4221. https://doi.org/10.3390/ijms21124221

AMA Style

Charytoniuk T, Zywno H, Konstantynowicz-Nowicka K, Berk K, Bzdega W, Chabowski A. Can Physical Activity Support the Endocannabinoid System in the Preventive and Therapeutic Approach to Neurological Disorders? International Journal of Molecular Sciences. 2020; 21(12):4221. https://doi.org/10.3390/ijms21124221

Chicago/Turabian Style

Charytoniuk, Tomasz; Zywno, Hubert; Konstantynowicz-Nowicka, Karolina; Berk, Klaudia; Bzdega, Wiktor; Chabowski, Adrian. 2020. "Can Physical Activity Support the Endocannabinoid System in the Preventive and Therapeutic Approach to Neurological Disorders?" Int. J. Mol. Sci. 21, no. 12: 4221. https://doi.org/10.3390/ijms21124221

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