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Open AccessArticle

Dynamic Changes of Heart Failure Biomarkers in Response to Parabolic Flight

1
Department of Internal Medicine II, Division of Cardiology, Paracelsus Medical University of Salzburg, 5020 Salzburg, Austria
2
Department of Internal Medicine I, Jena University Hospital, Friedrich Schiller University Jena, 07743 Jena, Germany
3
Division of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty, University Duesseldorf, 40225 Duesseldorf, Germany
4
Division of Cardiology and Rhythmology, Evangelical Hospital Hagen-Haspe, 58135 Hagen, Germany
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(10), 3467; https://doi.org/10.3390/ijms21103467
Received: 23 April 2020 / Revised: 6 May 2020 / Accepted: 12 May 2020 / Published: 14 May 2020
(This article belongs to the Special Issue Microgravity and Space Medicine)
Background: we aimed at investigating the influence of weightlessness and hypergravity by means of parabolic flight on the levels of the heart failure biomarkers H-FABP, sST2, IL-33, GDF-15, suPAR and Fetuin-A. Methods: 14 healthy volunteers (males: eight; mean age: 28.9) undergoing 31 short-term phases of weightlessness and hypergravity were included. At different time points (baseline, 1 h/24 h after parabolic flight), venous blood was drawn and analyzed by the use of ELISA. Results: sST2 evidenced a significant decrease 24 h after parabolic flight (baseline vs. 24, p = 0.009; 1 h vs. 24 h, p = 0.004). A similar finding was observed for GDF-15 (baseline vs. 24 h, p = 0.002; 1 h vs. 24 h, p = 0.025). The suPAR showed a significant decrease 24 h after parabolic flight (baseline vs. 24 h, p = 0.1726; 1 h vs. 24 h, p = 0.009). Fetuin-A showed a significant increase at 1 h and 24 h after parabolic flight (baseline vs. 24 h, p = 0.007; 1 h vs. 24 h, p = 0.04). H-FABP and IL-33 showed no significant differences at all time points. Conclusion: Our results suggest a reduction in cardiac stress induced by exposure to gravitational changes. Moreover, our findings indicate an influence of gravitational changes on proliferative processes and calcium homeostasis. View Full-Text
Keywords: space medicine; parabolic flight; microgravity; weightlessness; biomarkers; heart failure space medicine; parabolic flight; microgravity; weightlessness; biomarkers; heart failure
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Jirak, P.; Wernly, B.; Lichtenauer, M.; Paar, V.; Franz, M.; Knost, T.; Abusamrah, T.; Kelm, M.; Muessig, J.M.; Bimpong-Buta, N.-Y.; Jung, C. Dynamic Changes of Heart Failure Biomarkers in Response to Parabolic Flight. Int. J. Mol. Sci. 2020, 21, 3467.

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