Next Article in Journal
Detection of Nonylphenol with a Gold-Nanoparticle-Based Small-Molecule Sensing System Using an ssDNA Aptamer
Next Article in Special Issue
Intracellular Calcium Dysregulation by the Alzheimer’s Disease-Linked Protein Presenilin 2
Previous Article in Journal
Interaction Analysis of Commercial Graphene Oxide Nanoparticles with Unicellular Systems and Biomolecules
Previous Article in Special Issue
Examining Cardiomyocyte Dysfunction Using Acute Chemical Induction of an Ageing Phenotype
Open AccessArticle

Tonic Activation of Extrasynaptic NMDA Receptors Decreases Intrinsic Excitability and Promotes Bistability in a Model of Neuronal Activity

1
Laboratoire de Physiologie et Pharmacologie (CP604), Faculté de Médecine, Université Libre de Bruxelles, Route de Lennik 808, B-1070 Bruxelles, Belgium
2
Unité de Chronobiologie Théorique (CP231), Faculté des Sciences, Université Libre de Bruxelles, Boulevard du Triomphe, B-1050 Bruxelles, Belgium
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(1), 206; https://doi.org/10.3390/ijms21010206
Received: 25 November 2019 / Revised: 20 December 2019 / Accepted: 24 December 2019 / Published: 27 December 2019
NMDA receptors (NMDA-R) typically contribute to excitatory synaptic transmission in the central nervous system. While calcium influx through NMDA-R plays a critical role in synaptic plasticity, experimental evidence indicates that NMDAR-mediated calcium influx also modifies neuronal excitability through the activation of calcium-activated potassium channels. This mechanism has not yet been studied theoretically. Our theoretical model provides a simple description of neuronal electrical activity that takes into account the tonic activity of extrasynaptic NMDA receptors and a cytosolic calcium compartment. We show that calcium influx mediated by the tonic activity of NMDA-R can be coupled directly to the activation of calcium-activated potassium channels, resulting in an overall inhibitory effect on neuronal excitability. Furthermore, the presence of tonic NMDA-R activity promotes bistability in electrical activity by dramatically increasing the stimulus interval where both a stable steady state and repetitive firing can coexist. These results could provide an intrinsic mechanism for the constitution of memory traces in neuronal circuits. They also shed light on the way by which β -amyloids can alter neuronal activity when interfering with NMDA-R in Alzheimer’s disease and cerebral ischemia. View Full-Text
Keywords: calcium; neuron; NMDA receptor; excitability; bistability; memory; Alzheimer’s disease; cerebral ischemia calcium; neuron; NMDA receptor; excitability; bistability; memory; Alzheimer’s disease; cerebral ischemia
Show Figures

Graphical abstract

MDPI and ACS Style

Gall, D.; Dupont, G. Tonic Activation of Extrasynaptic NMDA Receptors Decreases Intrinsic Excitability and Promotes Bistability in a Model of Neuronal Activity. Int. J. Mol. Sci. 2020, 21, 206. https://doi.org/10.3390/ijms21010206

AMA Style

Gall D, Dupont G. Tonic Activation of Extrasynaptic NMDA Receptors Decreases Intrinsic Excitability and Promotes Bistability in a Model of Neuronal Activity. International Journal of Molecular Sciences. 2020; 21(1):206. https://doi.org/10.3390/ijms21010206

Chicago/Turabian Style

Gall, David; Dupont, Geneviève. 2020. "Tonic Activation of Extrasynaptic NMDA Receptors Decreases Intrinsic Excitability and Promotes Bistability in a Model of Neuronal Activity" Int. J. Mol. Sci. 21, no. 1: 206. https://doi.org/10.3390/ijms21010206

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop