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The Cross-Talk Between the TNF-α and RASSF-Hippo Signalling Pathways

Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PT, UK
Department of Biomedical Science, Faculty of Medicine, Universitas Airlangga, Surabaya 60132, Indonesia
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(9), 2346;
Received: 27 March 2019 / Revised: 7 May 2019 / Accepted: 8 May 2019 / Published: 11 May 2019
(This article belongs to the Special Issue Tumor Necrosis Factor (TNF))
The regulation of cell death through apoptosis is essential to a number of physiological processes. Defective apoptosis regulation is associated with many abnormalities including anomalies in organ development, altered immune response and the development of cancer. Several signalling pathways are known to regulate apoptosis including the Tumour Necrosis Factor-α (TNF-α) and Hippo signalling pathways. In this paper we review the cross-talk between the TNF-α pathway and the Hippo signalling pathway. Several molecules that tightly regulate the Hippo pathway, such as members of the Ras-association domain family member (RASSF) family proteins, interact and modulate some key proteins within the TNF-α pathway. Meanwhile, TNF-α stimulation also affects the expression and activation of core components of the Hippo pathway. This implies the crucial role of signal integration between these two major pathways in regulating apoptosis. View Full-Text
Keywords: TNF-α; Hippo pathway; RASSF; apoptosis; signalling pathway TNF-α; Hippo pathway; RASSF; apoptosis; signalling pathway
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MDPI and ACS Style

Oceandy, D.; Amanda, B.; Ashari, F.Y.; Faizah, Z.; Aziz, M.A.; Stafford, N. The Cross-Talk Between the TNF-α and RASSF-Hippo Signalling Pathways. Int. J. Mol. Sci. 2019, 20, 2346.

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