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Review

Presynaptic Calcium Channels

Department of Physiology, Tokyo Medical University, Tokyo 160-8402, Japan
Int. J. Mol. Sci. 2019, 20(9), 2217; https://doi.org/10.3390/ijms20092217
Received: 27 March 2019 / Revised: 22 April 2019 / Accepted: 26 April 2019 / Published: 6 May 2019
(This article belongs to the Special Issue Neurotransmitter Secretion and Release)
Presynaptic Ca2+ entry occurs through voltage-gated Ca2+ (CaV) channels which are activated by membrane depolarization. Depolarization accompanies neuronal firing and elevation of Ca2+ triggers neurotransmitter release from synaptic vesicles. For synchronization of efficient neurotransmitter release, synaptic vesicles are targeted by presynaptic Ca2+ channels forming a large signaling complex in the active zone. The presynaptic CaV2 channel gene family (comprising CaV2.1, CaV2.2, and CaV2.3 isoforms) encode the pore-forming α1 subunit. The cytoplasmic regions are responsible for channel modulation by interacting with regulatory proteins. This article overviews modulation of the activity of CaV2.1 and CaV2.2 channels in the control of synaptic strength and presynaptic plasticity. View Full-Text
Keywords: Ca2+ channels; synaptic transmission; G-proteins; synaptic proteins; Ca2+ binding proteins Ca2+ channels; synaptic transmission; G-proteins; synaptic proteins; Ca2+ binding proteins
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MDPI and ACS Style

Mochida, S. Presynaptic Calcium Channels. Int. J. Mol. Sci. 2019, 20, 2217. https://doi.org/10.3390/ijms20092217

AMA Style

Mochida S. Presynaptic Calcium Channels. International Journal of Molecular Sciences. 2019; 20(9):2217. https://doi.org/10.3390/ijms20092217

Chicago/Turabian Style

Mochida, Sumiko. 2019. "Presynaptic Calcium Channels" International Journal of Molecular Sciences 20, no. 9: 2217. https://doi.org/10.3390/ijms20092217

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