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The Crosstalk Between Cell Adhesion and Cancer Metabolism

by Bárbara Sousa 1,2, Joana Pereira 1,2 and Joana Paredes 1,2,3,*
Ipatimup-Institute of Molecular Pathology and Immunology of the University of Porto, 4200-135 Porto, Portugal
i3S, Institute of Investigation and Innovation in Health, 4200-135 Porto, Portugal
Medical Faculty of the University of Porto, 4200-135 Porto, Portugal
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(8), 1933;
Received: 27 March 2019 / Revised: 15 April 2019 / Accepted: 17 April 2019 / Published: 19 April 2019
(This article belongs to the Special Issue Cancer Cell Metabolism—Pathways and Biology)
Cancer cells preferentially use aerobic glycolysis over mitochondria oxidative phosphorylation for energy production, and this metabolic reprogramming is currently recognized as a hallmark of cancer. Oncogenic signaling frequently converges with this metabolic shift, increasing cancer cells’ ability to produce building blocks and energy, as well as to maintain redox homeostasis. Alterations in cell–cell and cell–extracellular matrix (ECM) adhesion promote cancer cell invasion, intravasation, anchorage-independent survival in circulation, and extravasation, as well as homing in a distant organ. Importantly, during this multi-step metastatic process, cells need to induce metabolic rewiring, in order to produce the energy needed, as well as to impair oxidative stress. Although the individual implications of adhesion molecules and metabolic reprogramming in cancer have been widely explored over the years, the crosstalk between cell adhesion molecular machinery and metabolic pathways is far from being clearly understood, in both normal and cancer contexts. This review summarizes our understanding about the influence of cell–cell and cell–matrix adhesion in the metabolic behavior of cancer cells, with a special focus concerning the role of classical cadherins, such as Epithelial (E)-cadherin and Placental (P)-cadherin. View Full-Text
Keywords: metabolism; cancer; adhesion; cadherin; ECM; cancer stem cells metabolism; cancer; adhesion; cadherin; ECM; cancer stem cells
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MDPI and ACS Style

Sousa, B.; Pereira, J.; Paredes, J. The Crosstalk Between Cell Adhesion and Cancer Metabolism. Int. J. Mol. Sci. 2019, 20, 1933.

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