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Int. J. Mol. Sci. 2019, 20(8), 1883;

Considerations for the Use of Polyphenols as Therapies in Neurodegenerative Diseases

Cellular Neurobiology, Department of Medical Biology, Université du Québec, Trois-Rivières, Québec, QC G9A5H7, Canada
Department of Psychiatry & Neuroscience, Université Laval and CHU Research Center, Ste-Foy, QC G1V 4G2, Canada
Author to whom correspondence should be addressed.
Received: 19 March 2019 / Revised: 4 April 2019 / Accepted: 12 April 2019 / Published: 16 April 2019
(This article belongs to the Special Issue Natural Products and Neuroprotection)
PDF [335 KB, uploaded 16 April 2019]


Over the last two decades, the increase in the incidence of neurodegenerative diseases due to the increasingly ageing population has resulted in a major social and economic burden. At present, a large body of literature supports the potential use of functional nutrients, which exhibit potential neuroprotective properties to mitigate these diseases. Among the most studied dietary molecules, polyphenols stand out because of their multiple and often overlapping reported modes of action. However, ambiguity still exists as to the significance of their influence on human health. This review discusses the characteristics and functions of polyphenols that shape their potential therapeutic actions in neurodegenerative diseases while the less-explored gaps in knowledge of these nutrients will also be highlighted. View Full-Text
Keywords: neurodegeneration; neuroprotection; nutraceuticals; bioavailability; stress response neurodegeneration; neuroprotection; nutraceuticals; bioavailability; stress response
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Renaud, J.; Martinoli, M.-G. Considerations for the Use of Polyphenols as Therapies in Neurodegenerative Diseases. Int. J. Mol. Sci. 2019, 20, 1883.

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