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Open AccessReview

Considerations for the Use of Polyphenols as Therapies in Neurodegenerative Diseases

1
Cellular Neurobiology, Department of Medical Biology, Université du Québec, Trois-Rivières, Québec, QC G9A5H7, Canada
2
Department of Psychiatry & Neuroscience, Université Laval and CHU Research Center, Ste-Foy, QC G1V 4G2, Canada
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(8), 1883; https://doi.org/10.3390/ijms20081883
Received: 19 March 2019 / Revised: 4 April 2019 / Accepted: 12 April 2019 / Published: 16 April 2019
(This article belongs to the Special Issue Natural Products and Neuroprotection)
Over the last two decades, the increase in the incidence of neurodegenerative diseases due to the increasingly ageing population has resulted in a major social and economic burden. At present, a large body of literature supports the potential use of functional nutrients, which exhibit potential neuroprotective properties to mitigate these diseases. Among the most studied dietary molecules, polyphenols stand out because of their multiple and often overlapping reported modes of action. However, ambiguity still exists as to the significance of their influence on human health. This review discusses the characteristics and functions of polyphenols that shape their potential therapeutic actions in neurodegenerative diseases while the less-explored gaps in knowledge of these nutrients will also be highlighted. View Full-Text
Keywords: neurodegeneration; neuroprotection; nutraceuticals; bioavailability; stress response neurodegeneration; neuroprotection; nutraceuticals; bioavailability; stress response
MDPI and ACS Style

Renaud, J.; Martinoli, M.-G. Considerations for the Use of Polyphenols as Therapies in Neurodegenerative Diseases. Int. J. Mol. Sci. 2019, 20, 1883. https://doi.org/10.3390/ijms20081883

AMA Style

Renaud J, Martinoli M-G. Considerations for the Use of Polyphenols as Therapies in Neurodegenerative Diseases. International Journal of Molecular Sciences. 2019; 20(8):1883. https://doi.org/10.3390/ijms20081883

Chicago/Turabian Style

Renaud, Justine; Martinoli, Maria-Grazia. 2019. "Considerations for the Use of Polyphenols as Therapies in Neurodegenerative Diseases" Int. J. Mol. Sci. 20, no. 8: 1883. https://doi.org/10.3390/ijms20081883

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Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

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