SUMOylation in Glioblastoma: A Novel Therapeutic Target
Department of Neurosurgery, University of Alabama at Birmingham, 1060 Faculty Office Tower, 510 20th Street South, Birmingham, AL 35223, USA
Medical Scientist Training Program, University of Alabama at Birmingham, 1825 University Boulevard, SHEL 121, Birmingham, AL 35294, USA
Department of Neurosurgery, University Hospital Frankfurt, Goethe-University, Schleusenweg 2-16, 60528 Frankfurt, Germany
Department of Biomedical and Biotechnological Sciences, Physiology Section, University of Catania, Via S. Sofia n. 97, Torre Biologica, 95123 Catania, Italy
Division of Neuroradiology, Department of Radiology, University of Alabama at Birmingham, Jefferson Tower N419—619 19th Street South, Birmingham, AL 35223, USA
Division of Pediatric Hematology and Oncology, Department of Pediatrics, University of Alabama at Birmingham, Lowder 512, 1600 7th Avenue South, Birmingham, AL 35223, USA
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
These authors jointly supervised this work.
Received: 24 March 2019 / Revised: 11 April 2019 / Accepted: 11 April 2019 / Published: 15 April 2019
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Protein SUMOylation is a dynamic post-translational modification which is involved in a diverse set of physiologic processes throughout the cell. Of note, SUMOylation also plays a role in the pathobiology of a myriad of cancers, one of which is glioblastoma (GBM). Accordingly, herein, we review core aspects of SUMOylation as it relates to GBM and in so doing highlight putative methods/modalities capable of therapeutically engaging the pathway for treatment of this deadly neoplasm.
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Fox, B.M.; Janssen, A.; Estevez-Ordonez, D.; Gessler, F.; Vicario, N.; Chagoya, G.; Elsayed, G.; Sotoudeh, H.; Stetler, W.; Friedman, G.K.; Bernstock, J.D. SUMOylation in Glioblastoma: A Novel Therapeutic Target. Int. J. Mol. Sci. 2019, 20, 1853.
Fox BM, Janssen A, Estevez-Ordonez D, Gessler F, Vicario N, Chagoya G, Elsayed G, Sotoudeh H, Stetler W, Friedman GK, Bernstock JD. SUMOylation in Glioblastoma: A Novel Therapeutic Target. International Journal of Molecular Sciences. 2019; 20(8):1853.
Fox, Brandon M.; Janssen, Andrew; Estevez-Ordonez, Dagoberto; Gessler, Florian; Vicario, Nunzio; Chagoya, Gustavo; Elsayed, Galal; Sotoudeh, Houman; Stetler, William; Friedman, Gregory K.; Bernstock, Joshua D. 2019. "SUMOylation in Glioblastoma: A Novel Therapeutic Target." Int. J. Mol. Sci. 20, no. 8: 1853.
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