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Apoptosis Induction byHistone Deacetylase Inhibitors in Cancer Cells: Role of Ku70

Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang 110016, China
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Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(7), 1601; https://doi.org/10.3390/ijms20071601
Received: 17 January 2019 / Revised: 16 March 2019 / Accepted: 18 March 2019 / Published: 30 March 2019
(This article belongs to the Special Issue Histone Deacetylase Inhibitors in Health and Disease)
Histone deacetylases (HDACs) are a group of enzymes that regulate gene transcription by controlling deacetylation of histones and non-histone proteins. Overexpression of HDACs is found in some types of tumors and predicts poor prognosis. Five HDAC inhibitors are approved for the treatment of cutaneous T-cell lymphoma, peripheral T-cell lymphoma, and multiple myeloma. Treatment with HDAC inhibitors regulates gene expression with increased acetylated histones with unconfirmed connection with therapy. Apoptosis is a key mechanism by which HDAC inhibitors selectively kill cancer cells, probably due to acetylation of non-histone proteins. Ku70 is a protein that repairs DNA breaks and stabilizes anti-apoptotic protein c-FLIP and proapoptotic protein Bax, which is regulated by acetylation. HDAC inhibitors induce Ku70 acetylation with repressed c-FLIP and activated Bax in cancer cells. Current studies indicate that Ku70 is a potential target of HDAC inhibitors and plays an important role during the induction of apoptosis. View Full-Text
Keywords: HDAC inhibitors; Ku70; apoptosis; Bax; c-FLIP; cancer HDAC inhibitors; Ku70; apoptosis; Bax; c-FLIP; cancer
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MDPI and ACS Style

Gong, P.; Wang, Y.; Jing, Y. Apoptosis Induction byHistone Deacetylase Inhibitors in Cancer Cells: Role of Ku70. Int. J. Mol. Sci. 2019, 20, 1601. https://doi.org/10.3390/ijms20071601

AMA Style

Gong P, Wang Y, Jing Y. Apoptosis Induction byHistone Deacetylase Inhibitors in Cancer Cells: Role of Ku70. International Journal of Molecular Sciences. 2019; 20(7):1601. https://doi.org/10.3390/ijms20071601

Chicago/Turabian Style

Gong, Ping; Wang, Yuetong; Jing, Yongkui. 2019. "Apoptosis Induction byHistone Deacetylase Inhibitors in Cancer Cells: Role of Ku70" Int. J. Mol. Sci. 20, no. 7: 1601. https://doi.org/10.3390/ijms20071601

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