Apoptosis Induction byHistone Deacetylase Inhibitors in Cancer Cells: Role of Ku70
Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang 110016, China
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(7), 1601; https://doi.org/10.3390/ijms20071601
Received: 17 January 2019 / Revised: 16 March 2019 / Accepted: 18 March 2019 / Published: 30 March 2019
(This article belongs to the Special Issue Histone Deacetylase Inhibitors in Health and Disease)
Histone deacetylases (HDACs) are a group of enzymes that regulate gene transcription by controlling deacetylation of histones and non-histone proteins. Overexpression of HDACs is found in some types of tumors and predicts poor prognosis. Five HDAC inhibitors are approved for the treatment of cutaneous T-cell lymphoma, peripheral T-cell lymphoma, and multiple myeloma. Treatment with HDAC inhibitors regulates gene expression with increased acetylated histones with unconfirmed connection with therapy. Apoptosis is a key mechanism by which HDAC inhibitors selectively kill cancer cells, probably due to acetylation of non-histone proteins. Ku70 is a protein that repairs DNA breaks and stabilizes anti-apoptotic protein c-FLIP and proapoptotic protein Bax, which is regulated by acetylation. HDAC inhibitors induce Ku70 acetylation with repressed c-FLIP and activated Bax in cancer cells. Current studies indicate that Ku70 is a potential target of HDAC inhibitors and plays an important role during the induction of apoptosis.
View Full-Text
▼
Show Figures
Figure 1
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
MDPI and ACS Style
Gong, P.; Wang, Y.; Jing, Y. Apoptosis Induction byHistone Deacetylase Inhibitors in Cancer Cells: Role of Ku70. Int. J. Mol. Sci. 2019, 20, 1601. https://doi.org/10.3390/ijms20071601
AMA Style
Gong P, Wang Y, Jing Y. Apoptosis Induction byHistone Deacetylase Inhibitors in Cancer Cells: Role of Ku70. International Journal of Molecular Sciences. 2019; 20(7):1601. https://doi.org/10.3390/ijms20071601
Chicago/Turabian StyleGong, Ping; Wang, Yuetong; Jing, Yongkui. 2019. "Apoptosis Induction byHistone Deacetylase Inhibitors in Cancer Cells: Role of Ku70" Int. J. Mol. Sci. 20, no. 7: 1601. https://doi.org/10.3390/ijms20071601
Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.
Search more from Scilit
