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Open AccessReview

NFkappaB is a Key Player in the Crosstalk between Inflammation and Cardiovascular Diseases

1
Department of Advanced Biomedical Sciences, Federico II University of Naples, 80131 Napoli, Italy
2
Division of Cardiac Surgery, AOU San Giovanni di Dio e Ruggi d’Aragona, 84131 Salerno, Italy
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(7), 1599; https://doi.org/10.3390/ijms20071599
Received: 19 February 2019 / Revised: 21 March 2019 / Accepted: 26 March 2019 / Published: 30 March 2019
(This article belongs to the Special Issue Mechanisms of Inflammation in Degenerative Cardiovascular Conditions)
Inflammation is a key mechanism of cardiovascular diseases. It is an essential component of atherosclerosis and a significant risk factor for the development of cardiovascular events. In the crosstalk between inflammation and cardiovascular diseases, the transcription factor NFκB seems to be a key player since it is involved in the development and progression of both inflammation and cardiac and vascular damage. In this review, we deal with the recent findings of the role of inflammation in cardiac diseases, focusing, in particular, on NFκB as a functional link. We describe strategies for the therapeutic targeting of NFκB as a potential strategy for the failing heart. View Full-Text
Keywords: inflammation; cardiovascular diseases; NFκB; GRK inflammation; cardiovascular diseases; NFκB; GRK
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MDPI and ACS Style

Fiordelisi, A.; Iaccarino, G.; Morisco, C.; Coscioni, E.; Sorriento, D. NFkappaB is a Key Player in the Crosstalk between Inflammation and Cardiovascular Diseases. Int. J. Mol. Sci. 2019, 20, 1599. https://doi.org/10.3390/ijms20071599

AMA Style

Fiordelisi A, Iaccarino G, Morisco C, Coscioni E, Sorriento D. NFkappaB is a Key Player in the Crosstalk between Inflammation and Cardiovascular Diseases. International Journal of Molecular Sciences. 2019; 20(7):1599. https://doi.org/10.3390/ijms20071599

Chicago/Turabian Style

Fiordelisi, Antonella; Iaccarino, Guido; Morisco, Carmine; Coscioni, Enrico; Sorriento, Daniela. 2019. "NFkappaB is a Key Player in the Crosstalk between Inflammation and Cardiovascular Diseases" Int. J. Mol. Sci. 20, no. 7: 1599. https://doi.org/10.3390/ijms20071599

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