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Open AccessCommentary
Int. J. Mol. Sci. 2019, 20(3), 772; https://doi.org/10.3390/ijms20030772

Mini Review/Commentary: Growth Hormone Treatment in Children with Type 1 Diabetes

1
Department of Pediatrics, Technical University München, D-80804 Munich, Germany
2
Department of Pediatrics, Klinikum Wels-Grieskirchen, Grieskirchner Str. 42, A-4600 Wels, Austria
3
Institute of Epidemiology and Medical Biometry, University of Ulm, D-89019 Ulm, Germany
4
German Center for Diabetes Research (DZD), D-85764 Munich-Neuherberg, Germany
*
Author to whom correspondence should be addressed.
Received: 9 January 2019 / Accepted: 10 February 2019 / Published: 12 February 2019
Full-Text   |   PDF [158 KB, uploaded 12 February 2019]   |   Review Reports

Abstract

In the state of insulin deficiency, the growth hormone—insulin-like growth factor-I (GH–IGF-I) axis is altered due to hepatic GH resistance, which leads to GH hypersecretion and low circulating IGF-I concentration. On the other hand, both growth hormone deficiency (GHD) and GH excess have significant influence on carbohydrate metabolism. These complex interactions are challenging in diagnosing GHD in subjects with type 1 diabetes mellitus (T1DM) and in treating subjects with T1DM with GH. So far, there is only limited clinical experience in GH treatment in patients with T1DM, but recently first reports on metabolic safety and efficacy of GH treatment in subjects with T1DM have been published. View Full-Text
Keywords: growth hormone; type 1 diabetes; growth hormone treatment; GH–IGF-I axis growth hormone; type 1 diabetes; growth hormone treatment; GH–IGF-I axis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Bonfig, W.; Holl, R.W. Mini Review/Commentary: Growth Hormone Treatment in Children with Type 1 Diabetes. Int. J. Mol. Sci. 2019, 20, 772.

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