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Int. J. Mol. Sci. 2019, 20(3), 771; https://doi.org/10.3390/ijms20030771

Lymphoproliferation Impairment and Oxidative Stress in Blood Cells from Early Parkinson’s Disease Patients

1
Department of Genetics, Physiology and Microbiology, Faculty of Biology, Complutense University of Madrid, 28040 Madrid, Spain
2
Institute of Biomedical Research Hospital 12 Octubre (imas12), 28041 Madrid, Spain
3
Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), 28040 Madrid, Spain
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Received: 28 December 2018 / Revised: 28 January 2019 / Accepted: 2 February 2019 / Published: 12 February 2019
(This article belongs to the Special Issue Immunosenescence and Related Processes)
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Abstract

In Parkinson’s Disease (PD), the peripheral changes in the functional capacity and redox state of immune cells has been scarcely investigated, especially in the early PD stages. Aging is a risk factor for PD, and the age-related impairment of the immune system, based on a chronic-oxidative stress situation, is involved in the rate of aging. We analyzed several functions in isolated peripheral blood neutrophils and mononuclear cells from PD stage 2 patients, and compared the results to those in healthy elderly and adult controls. Several oxidative stress and damage parameters were studied in whole blood cells. The results showed an impairment of the lymphoproliferative response in stimulated conditions in the PD patients compared with age-matched controls, who also showed typical immunosenescence in comparison with adult individuals. Higher oxidative stress and damage were observed in whole blood cells from PD patients (lower glutathione peroxidase activity, and higher oxidized glutathione and malondialdehyde contents). Our results suggest an accelerated immunosenescence in PD stage 2, and that several of the parameters studied could be appropriate peripheral biomarkers in the early stages of PD. View Full-Text
Keywords: biomarkers; blood cells; immune functions; immunosenescence; lymphoproliferation; oxidative damage; oxidative stress; Parkinson’s Disease biomarkers; blood cells; immune functions; immunosenescence; lymphoproliferation; oxidative damage; oxidative stress; Parkinson’s Disease
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Vida, C.; Kobayashi, H.; Garrido, A.; Martínez de Toda, I.; Carro, E.; Molina, J.A.; De la Fuente, M. Lymphoproliferation Impairment and Oxidative Stress in Blood Cells from Early Parkinson’s Disease Patients. Int. J. Mol. Sci. 2019, 20, 771.

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