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Open AccessCommunication
Int. J. Mol. Sci. 2019, 20(2), 288; https://doi.org/10.3390/ijms20020288

Growth Factor Quantification of Platelet-Rich Plasma in Burn Patients Compared to Matched Healthy Volunteers

1
Department of Plastic, Reconstructive & Hand Surgery, Amsterdam UMC, University of Amsterdam, 1081 HV Amsterdam, The Netherlands
2
Burn Center, Red Cross Hospital, 1942 LE Beverwijk, The Netherlands
3
Department of Plastic, Reconstructive & Hand Surgery, Amsterdam Movement Sciences Research Institute, Amsterdam UMC, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands
4
Association of Dutch Burn Centers, 1942 LE Beverwijk, The Netherlands
5
Department of Surgery, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands
*
Author to whom correspondence should be addressed.
Received: 24 November 2018 / Revised: 7 January 2019 / Accepted: 8 January 2019 / Published: 12 January 2019
(This article belongs to the Special Issue Blood-Derived Products for Tissue Repair/Regeneration)
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Abstract

Platelet rich plasma (PRP) is blood plasma with a platelet concentration above baseline. When activated, PRP releases growth factors involved in all stages of wound healing, potentially boosting the healing process. To expand our knowledge of the effectiveness of PRP, it is crucial to know the content and composition of PRP products. In this study, growth factor quantification measurements of PRP from burn patients and gender- and age-matched controls were performed. The PRP of burn patients showed levels of growth factors comparable to those of the PRP of healthy volunteers. Considerable intra-individual variation in growth factor content was found. However, a correlation was found between the platelet count of the PRP and most of the growth factors measured. View Full-Text
Keywords: platelets; burns; growth factors; platelet rich plasma; quantification platelets; burns; growth factors; platelet rich plasma; quantification
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Marck, R.E.; Gardien, K.L.M.; Vlig, M.; Breederveld, R.S.; Middelkoop, E. Growth Factor Quantification of Platelet-Rich Plasma in Burn Patients Compared to Matched Healthy Volunteers. Int. J. Mol. Sci. 2019, 20, 288.

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