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Int. J. Mol. Sci. 2019, 20(2), 289; https://doi.org/10.3390/ijms20020289

Metabolomic Approach in STEMI-Patients Undergoing Left Ventricular Remodeling

1
Institut Mitovasc, University of Angers, University Hospital of Angers, 49000 Angers, France
2
UMR CNRS 6015-INSERMU1083, 49000 Angers, France
3
Department of Cardiology, University Hospital of Angers, 49000 Angers, France
4
Department of Biochemistry, University Hospital of Angers, 49000 Angers, France
*
Author to whom correspondence should be addressed.
Received: 27 November 2018 / Revised: 4 January 2019 / Accepted: 8 January 2019 / Published: 12 January 2019
(This article belongs to the Section Molecular Biology)
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Abstract

Left ventricular remodeling (LVR) occurring after ST-segment elevation myocardial infarction (STEMI) is frequent and severe. We present a metabolomic approach as an attempt to reveal unknown biomarkers associated with post-STEMI LVR. Out of 192 consecutive patients with successfully revascularized STEMI, 32 presented LVR and were clinically matched with 32 no-LVR patients. They underwent cardiac magnetic resonance at baseline, three months and 12 months. Blood samples were collected during index hospitalization. Creatine kinase (CK) peak and inflammatory markers were higher for LVR patients compared to no-LVR patients (mean 3466 ± 2211 and 2394 ± 1615 UI/L respectively, p = 0.005 for CK peak; mean 35.9 ± 44.3 vs. 21.7 ± 30.4 mg/L respectively, p = 0.020 for C-reactive protein). Leukocyte and neutrophil counts were also higher for LVR patients (mean 12028 ± 2593/mL vs. 10346 ± 3626/mL respectively, p = 0.028 and mean 9035 ± 3036/mL vs. 7596 ± 3822/mL respectively, p < 0.001). For metabolomic analysis, sphingomyelin C20:2 and symmetrical dimethylarginine were higher for LVR patients, but did not reach significance after the correction for the alpha risk. The metabolomic approach did not discriminate patients with and without LVR. However, common parameters that focus on infarction severity, such as infarct size and inflammatory markers, differed between the groups. View Full-Text
Keywords: left ventricular remodeling; myocardial infarction; metabolomics; cardiac magnetic resonance left ventricular remodeling; myocardial infarction; metabolomics; cardiac magnetic resonance
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Garcia, G.; Chao de la Barca, J.M.; Mirebeau-Prunier, D.; Reynier, P.; Furber, A.; Prunier, F.; Bière, L. Metabolomic Approach in STEMI-Patients Undergoing Left Ventricular Remodeling. Int. J. Mol. Sci. 2019, 20, 289.

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