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Open AccessArticle

Synergistic Neuroprotective Effect of Schisandra chinensis and Ribes fasciculatum on Neuronal Cell Death and Scopolamine-Induced Cognitive Impairment in Rats

1
Department of Medical Genetics, Ajou University School of Medicine, Suwon 16499, Korea
2
Department of Biomedical Sciences, Ajou University Graduate School of Medicine, Suwon 16499, Korea
3
Department of Biochemistry, Chungnam National University School of Medicine, Daejeon 301747, Korea
4
Research Institute for Medical Science Chungnam National University School of Medicine, Daejeon 301747, Korea
5
Rpbio Research Institute, Rpbio Co. Ltd., Suwon 16229, Korea
6
NineB Research Institute, Nine B Co. Ltd., Suwon 16499, Korea
7
Natural Products Research Team, Gyeonggi Business & Science Accelerator, Suwon 16229, Korea
8
Department of Medical Science, Chungnam National University School of Medicine, Daejeon 301747, Korea
9
Infection Control Convergence Research Center, Chungnam National University School of Medicine, Daejeon 301747, Korea
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2019, 20(18), 4517; https://doi.org/10.3390/ijms20184517
Received: 16 August 2019 / Revised: 1 September 2019 / Accepted: 6 September 2019 / Published: 12 September 2019
Mild cognitive impairment (MCI) is considered as a transitional stage between aging and Alzheimer’s disease. In the present study, we examined the protective effect of Schisandra chinensis (SC) and Ribes fasciculatum (RF) on neuronal cell death in vitro and scopolamine-induced cognitive impairment in Sprague Dawley® rats in vivo. A mixture of SC and RF extracts (SC+RF) significantly protected against hydrogen peroxide-induced PC12 neuronal cell death. The neuroprotective effect of SC+RF on scopolamine-induced memory impairment in rats was evaluated using the passive avoidance test and the Morris water maze test. In the passive avoidance test, SC+RF-treated rats showed an increased latency to escape, compared to the scopolamine-treated rats. Moreover, SC+RF treatment significantly reduced escape latency in water maze test, compared to treatment with scopolamine alone. To verify the long-term memory, we performed probe test of water maze test. As a result, rat treated with SC+RF spent more time in the target quadrant. Consistent with enhancement of memory function, the brain derived neurotrophic factor (BDNF) and its downstream molecules (pERK, pATK, and pCREB) are increased in SC+RF treatment in hippocampal area compared with scopolamine treated group. These results suggest that a mixture of SC and RF extracts may be a good therapeutic candidate for preventing mild cognitive impairment. View Full-Text
Keywords: herbal medicine; Schisandra chinensis; Ribes fasciculatum; neuroprotection; neuronal cell death; ccopolamine-induced cognitive impairment herbal medicine; Schisandra chinensis; Ribes fasciculatum; neuroprotection; neuronal cell death; ccopolamine-induced cognitive impairment
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Park, E.; Ryu, M.J.; Kim, N.K.; Bae, M.H.; Seo, Y.; Kim, J.; Yeo, S.; Kanwal, M.; Choi, C.W.; Heo, J.Y.; Jeong, S.-Y. Synergistic Neuroprotective Effect of Schisandra chinensis and Ribes fasciculatum on Neuronal Cell Death and Scopolamine-Induced Cognitive Impairment in Rats. Int. J. Mol. Sci. 2019, 20, 4517.

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