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Dietary Polyphenols: A Multifactorial Strategy to Target Alzheimer’s Disease

1
School of Science, RMIT University, Bundoora, Victoria 3083, Australia
2
Mushroom Research Centre, University of Malaya, 50603 Kuala Lumpur, Malaysia
3
Department of Anatomy, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
4
Department of Pharmaceutical Life Sciences, Faculty of Pharmacy, University of Malaya, 50603 Kuala Lumpur, Malaysia
5
Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(20), 5090; https://doi.org/10.3390/ijms20205090
Received: 19 September 2019 / Revised: 11 October 2019 / Accepted: 11 October 2019 / Published: 14 October 2019
Ageing is an inevitable fundamental process for people and is their greatest risk factor for neurodegenerative disease. The ageing processes bring changes in cells that can drive the organisms to experience loss of nutrient sensing, disrupted cellular functions, increased oxidative stress, loss of cellular homeostasis, genomic instability, accumulation of misfolded protein, impaired cellular defenses and telomere shortening. Perturbation of these vital cellular processes in neuronal cells can lead to life threatening neurological disorders like Alzheimer’s Disease, Parkinson’s Disease, Huntington’s Disease, Lewy body dementia, etc. Alzheimer’s Disease is the most frequent cause of deaths in the elderly population. Various therapeutic molecules have been designed to overcome the social, economic and health care burden caused by Alzheimer’s Disease. Almost all the chemical compounds in clinical practice have been found to treat symptoms only limiting them to palliative care. The reason behind such imperfect drugs may result from the inefficiencies of the current drugs to target the cause of the disease. Here, we review the potential role of antioxidant polyphenolic compounds that could possibly be the most effective preventative strategy against Alzheimer’s Disease. View Full-Text
Keywords: Alzheimer’s Disease; amyloid beta; antioxidant; longevity; mushroom; neuroprotection; nutraceuticals; protein homeostasis; polyphenol Alzheimer’s Disease; amyloid beta; antioxidant; longevity; mushroom; neuroprotection; nutraceuticals; protein homeostasis; polyphenol
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MDPI and ACS Style

Dhakal, S.; Kushairi, N.; Phan, C.W.; Adhikari, B.; Sabaratnam, V.; Macreadie, I. Dietary Polyphenols: A Multifactorial Strategy to Target Alzheimer’s Disease. Int. J. Mol. Sci. 2019, 20, 5090. https://doi.org/10.3390/ijms20205090

AMA Style

Dhakal S, Kushairi N, Phan CW, Adhikari B, Sabaratnam V, Macreadie I. Dietary Polyphenols: A Multifactorial Strategy to Target Alzheimer’s Disease. International Journal of Molecular Sciences. 2019; 20(20):5090. https://doi.org/10.3390/ijms20205090

Chicago/Turabian Style

Dhakal, Sudip; Kushairi, Naufal; Phan, Chia W.; Adhikari, Benu; Sabaratnam, Vikineswary; Macreadie, Ian. 2019. "Dietary Polyphenols: A Multifactorial Strategy to Target Alzheimer’s Disease" Int. J. Mol. Sci. 20, no. 20: 5090. https://doi.org/10.3390/ijms20205090

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