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Targeting Cellular Metabolism Modulates Head and Neck Oncogenesis

1,†, 1,†, 1,2,3, 1,2,3,4 and 1,2,4,*
1
Institute of Oral Biology, School of Dentistry, National Yang-Ming University, Taipei 11221, Taiwan
2
Department of Dentistry, School of Dentistry, National Yang-Ming University, Taipei 11221, Taiwan
3
Department of Stomatology, Taipei Veterans General Hospital, Taipei 11217, Taiwan
4
Cancer Progression Research Center, National Yang-Ming University, Taipei 11221, Taiwan
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2019, 20(16), 3960; https://doi.org/10.3390/ijms20163960
Received: 1 August 2019 / Revised: 12 August 2019 / Accepted: 13 August 2019 / Published: 14 August 2019
(This article belongs to the Special Issue Oral Fibrosis and Oral Cancer: From Molecular Targets to Therapeutics)
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PDF [1985 KB, uploaded 14 August 2019]
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Abstract

Considering the great energy and biomass demand for cell survival, cancer cells exhibit unique metabolic signatures compared to normal cells. Head and neck squamous cell carcinoma (HNSCC) is one of the most prevalent neoplasms worldwide. Recent findings have shown that environmental challenges, as well as intrinsic metabolic manipulations, could modulate HNSCC experimentally and serve as clinic prognostic indicators, suggesting that a better understanding of dynamic metabolic changes during HNSCC development could be of great benefit for developing adjuvant anti-cancer schemes other than conventional therapies. However, the following questions are still poorly understood: (i) how does metabolic reprogramming occur during HNSCC development? (ii) how does the tumorous milieu contribute to HNSCC tumourigenesis? and (iii) at the molecular level, how do various metabolic cues interact with each other to control the oncogenicity and therapeutic sensitivity of HNSCC? In this review article, the regulatory roles of different metabolic pathways in HNSCC and its microenvironment in controlling the malignancy are therefore discussed in the hope of providing a systemic overview regarding what we knew and how cancer metabolism could be translated for the development of anti-cancer therapeutic reagents. View Full-Text
Keywords: head and neck cancer; metabolic reprogramming; tumor microenvironment; non-coding RNA; targeted therapy head and neck cancer; metabolic reprogramming; tumor microenvironment; non-coding RNA; targeted therapy
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Hsieh, Y.-T.; Chen, Y.-F.; Lin, S.-C.; Chang, K.-W.; Li, W.-C. Targeting Cellular Metabolism Modulates Head and Neck Oncogenesis. Int. J. Mol. Sci. 2019, 20, 3960.

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