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Arctigenin Reduces Myofibroblast Activities in Oral Submucous Fibrosis by LINC00974 Inhibition
Review

Oral Submucous Fibrosis: A Review on Etiopathogenesis, Diagnosis, and Therapy

by 1,†, 2,3,4,5,†, 6,* and 7,*
1
Department of Healthcare Administration, Asia University, Taichung 41354, Taiwan
2
Tissue Bank, Chang Gung Memorial Hospital, Taoyuan 33305, Taiwan
3
Research Center for Industry of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 33303, Taiwan
4
Graduate Institute of Health Industry Technology, Chang Gung University of Science and Technology, Taoyuan 33303, Taiwan
5
Liver Research Center, Chang Gung Memorial Hospital, Taoyuan 33305, Taiwan
6
Department of Dental Hygiene, College of Health Care, China Medical University, Taichung 40402, Taiwan
7
Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2019, 20(12), 2940; https://doi.org/10.3390/ijms20122940
Received: 14 May 2019 / Revised: 10 June 2019 / Accepted: 14 June 2019 / Published: 16 June 2019
(This article belongs to the Special Issue Oral Fibrosis and Oral Cancer: From Molecular Targets to Therapeutics)
Oral submucous fibrosis (OSF) is characterized by abnormal collagen deposition. It is a precancerous disorder and transforms into a malignant tumor in 1.5–15% of all cases. Symptoms include submucous fibrosis, ulceration, xerostomia, a burning sensation, and restricted mouth opening. All of these greatly interfere with patient quality of life. The present review introduces OSF from a molecular perspective and summarizes what is known about its underlying mechanisms, diagnostic biomarkers, and therapeutic interventions. In addition to the aggressive treatment of OSF, its prevention is also important. Future research should, therefore, focus on improving the oral health literacy of the patients susceptible to OSF. View Full-Text
Keywords: collagen deposition; diagnostic biomarkers; oral submucous fibrosis (OSF); precancerous disorder; therapeutic interventions; underlying mechanisms collagen deposition; diagnostic biomarkers; oral submucous fibrosis (OSF); precancerous disorder; therapeutic interventions; underlying mechanisms
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MDPI and ACS Style

Shih, Y.-H.; Wang, T.-H.; Shieh, T.-M.; Tseng, Y.-H. Oral Submucous Fibrosis: A Review on Etiopathogenesis, Diagnosis, and Therapy. Int. J. Mol. Sci. 2019, 20, 2940. https://doi.org/10.3390/ijms20122940

AMA Style

Shih Y-H, Wang T-H, Shieh T-M, Tseng Y-H. Oral Submucous Fibrosis: A Review on Etiopathogenesis, Diagnosis, and Therapy. International Journal of Molecular Sciences. 2019; 20(12):2940. https://doi.org/10.3390/ijms20122940

Chicago/Turabian Style

Shih, Yin-Hwa, Tong-Hong Wang, Tzong-Ming Shieh, and Yu-Hsin Tseng. 2019. "Oral Submucous Fibrosis: A Review on Etiopathogenesis, Diagnosis, and Therapy" International Journal of Molecular Sciences 20, no. 12: 2940. https://doi.org/10.3390/ijms20122940

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