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Effect of the Large and Small T-Antigens of Human Polyomaviruses on Signaling Pathways

1
Molecular Inflammation Research Group, Department of Medical Biology, Faculty of Health Sciences, UiT The Arctic University of Norway, 9019 Tromsø, Norway
2
School of Molecular and Cellular Biology, Astbury Centre for Structural Molecular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(16), 3914; https://doi.org/10.3390/ijms20163914
Received: 22 July 2019 / Revised: 9 August 2019 / Accepted: 10 August 2019 / Published: 12 August 2019
(This article belongs to the Special Issue Role of Signaling Pathways in the Viral Life Cycle)
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Abstract

Viruses are intracellular parasites that require a permissive host cell to express the viral genome and to produce new progeny virus particles. However, not all viral infections are productive and some viruses can induce carcinogenesis. Irrespective of the type of infection (productive or neoplastic), viruses hijack the host cell machinery to permit optimal viral replication or to transform the infected cell into a tumor cell. One mechanism viruses employ to reprogram the host cell is through interference with signaling pathways. Polyomaviruses are naked, double-stranded DNA viruses whose genome encodes the regulatory proteins large T-antigen and small t-antigen, and structural proteins that form the capsid. The large T-antigens and small t-antigens can interfere with several host signaling pathways. In this case, we review the interplay between the large T-antigens and small t-antigens with host signaling pathways and the biological consequences of these interactions. View Full-Text
Keywords: apoptosis; DNA damage response; immune response; interferon; MAP kinase; NFκB; p53; PI3K; protein phosphatases; retinoblastoma apoptosis; DNA damage response; immune response; interferon; MAP kinase; NFκB; p53; PI3K; protein phosphatases; retinoblastoma
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Moens, U.; Macdonald, A. Effect of the Large and Small T-Antigens of Human Polyomaviruses on Signaling Pathways. Int. J. Mol. Sci. 2019, 20, 3914.

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