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A Narrative Role of Vitamin D and Its Receptor: With Current Evidence on the Gastric Tissues

1
Department of Biology, College of Science, United Arab Emirates University (UAEU), Al Ain P.O. Box 15551, UAE
2
Department of Chemistry, College of Science, United Arab Emirates University (UAEU), Al Ain P.O. Box 15551, UAE
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(15), 3832; https://doi.org/10.3390/ijms20153832
Received: 1 July 2019 / Revised: 30 July 2019 / Accepted: 1 August 2019 / Published: 5 August 2019
Vitamin D is a major steroid hormone that is gaining attention as a therapeutic molecule. Due to the general awareness of its importance for the overall well-being, vitamin D deficiency (VDD) is now recognized as a major health issue. The main reason for VDD is minimal exposure to sunlight. The vitamin D receptor (VDR) is a member of the steroid hormone receptors that induces a cascade of cell signaling to maintain healthy Ca2+ levels that serve to regulate several biological functions. However, the roles of vitamin D and its metabolism in maintaining gastric homeostasis have not yet been completely elucidated. Currently, there is a need to increase the vitamin D status in individuals worldwide as it has been shown to improve musculoskeletal health and reduce the risk of chronic illnesses, including some cancers, autoimmune and infectious diseases, type 2 diabetes mellitus, neurocognitive disorders, and general mortality. The role of vitamin D in gastric homeostasis is crucial and unexplored. This review attempts to elucidate the central role of vitamin D in preserving and maintaining the overall health and homeostasis of the stomach tissue. View Full-Text
Keywords: 1α,25(OH)2D; vitamin D deficiency; vitamin D epimers; cytochrome P450; 1,25-MARRS; stomach 1α,25(OH)2D; vitamin D deficiency; vitamin D epimers; cytochrome P450; 1,25-MARRS; stomach
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Sirajudeen, S.; Shah, I.; Al Menhali, A. A Narrative Role of Vitamin D and Its Receptor: With Current Evidence on the Gastric Tissues. Int. J. Mol. Sci. 2019, 20, 3832.

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