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Current Knowledge of the Potential Links between Inflammation and Prostate Cancer

Department of Urology, Santa Chiara Regional Hospital, 38122 Trento, Italy
Careggi University Hospital, 50134 Florence, Italy
Department of Health Sciences, University of Florence, 50139 Florence, Italy
Department of Biotechnology and Life Sciences, Università degli Studi dell’Insubria, 21100 Busto Arsizio, Italy
Department of Urology, Oslo University Hospital, 0424 Oslo, Norway
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(15), 3833;
Received: 29 May 2019 / Revised: 28 July 2019 / Accepted: 5 August 2019 / Published: 6 August 2019
(This article belongs to the Special Issue Inflammation and Cancer 2018)
Inflammation is inherent in prostatic diseases and it is now accepted that it may facilitate cellular proliferation in both benign and malignant conditions. The strong relationship between prostatic inflammation and pathogenesis of benign prostatic hyperplasia (BPH) is supported by epidemiologic, histopathologic and molecular evidence. Contrariwise, the role of inflammation in prostate carcinogenesis is still controversial, although current data indicate that the inflammatory microenvironment can regulate prostate cancer (PCa) growth and progression. Knowledge of the complex molecular landscape associated with chronic inflammation in the context of PCa may lead to the introduction and optimization of novel targeted therapies. In this perspective, evaluation of the inflammatory component in prostate specimens could be included in routine pathology reports. View Full-Text
Keywords: prostate cancer; inflammation; prostatitis; review; progression prostate cancer; inflammation; prostatitis; review; progression
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Cai, T.; Santi, R.; Tamanini, I.; Galli, I.C.; Perletti, G.; Bjerklund Johansen, T.E.; Nesi, G. Current Knowledge of the Potential Links between Inflammation and Prostate Cancer. Int. J. Mol. Sci. 2019, 20, 3833.

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