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Anti-Obesity Effects of Dietary Calcium: The Evidence and Possible Mechanisms

1
Guangdong Provincial Key Laboratory of Animal Nutrition Control, College of Animal Science, South China Agricultural University, Guangzhou 510642, China
2
National Engineering Research Center for Breeding Swine Industry and ALLTECH-SCAU Animal Nutrition Control Research Alliance, South China Agricultural University, Guangzhou 510642, China
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(12), 3072; https://doi.org/10.3390/ijms20123072
Received: 18 April 2019 / Revised: 18 June 2019 / Accepted: 20 June 2019 / Published: 23 June 2019
(This article belongs to the Special Issue Adipogenesis and Adipose Tissue Metabolism)
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PDF [696 KB, uploaded 23 June 2019]
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Abstract

Obesity is a serious health challenge worldwide and is associated with various comorbidities, including dyslipidemia, type 2 diabetes, and cardiovascular disease. Developing effective strategies to prevent obesity is therefore of paramount importance. One potential strategy to reduce obesity is to consume calcium, which has been implicated to be involved in reducing body weight/fat. In this review, we compile the evidence for the anti-obesity roles of calcium in cells, animals, and humans. In addition, we summarize the possible anti-obesity mechanisms of calcium, including regulation of (a) adipogenesis, (b) fat metabolism, (c) adipocyte (precursor) proliferation and apoptosis, (d) thermogenesis, (e) fat absorption and excretion, and (f) gut microbiota. Although the exact anti-obesity roles of calcium in different subjects and how calcium induces the proposed anti-obesity mechanisms need to be further investigated, the current evidence demonstrates the anti-obesity effects of calcium and suggests the potential application of dietary calcium for prevention of obesity. View Full-Text
Keywords: anti-obesity; calcium; adipogenesis; fat metabolism; proliferation and apoptosis; thermogenesis; fecal fat excretion; gut microbiota anti-obesity; calcium; adipogenesis; fat metabolism; proliferation and apoptosis; thermogenesis; fecal fat excretion; gut microbiota
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Zhang, F.; Ye, J.; Zhu, X.; Wang, L.; Gao, P.; Shu, G.; Jiang, Q.; Wang, S. Anti-Obesity Effects of Dietary Calcium: The Evidence and Possible Mechanisms. Int. J. Mol. Sci. 2019, 20, 3072.

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