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Leptin and Ghrelin in Excessive Gestational Weight Gain—Association between Mothers and Offspring

1
Chair and Department of Obstetrics and Perinatology, Medical University of Lublin, Lublin 20-090, Poland
2
Chair and Department of Internal Medicine, Medical University of Lublin, Lublin 20-081, Poland
3
Chair and Department of Human Physiology, Medical University of Lublin, Lublin 20-080, Poland
4
Department of Gynecology and Obstetrics, Institute of Clinical and Experimental Medicine, Medical Faculty, University of Rzeszow, Rzeszów 35-959, Poland
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(10), 2398; https://doi.org/10.3390/ijms20102398
Received: 13 March 2019 / Revised: 6 May 2019 / Accepted: 13 May 2019 / Published: 15 May 2019
(This article belongs to the Special Issue Adipokines 2.0)
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Abstract

Two-thirds of pregnant women exceed gestational weight gain recommendations. Excessive gestational weight gain (EGWG) appears to be associated with offspring’s complications induced by mechanisms that are still unclear. The aim of this study was to investigate whether umbilical cord leptin (UCL) and ghrelin (UCG) concentrations are altered in full-term neonates born to EGWG mothers and whether neonatal anthropometric measurements correlate with UCL and UCG levels and maternal serum ghrelin and leptin as well as urine ghrelin concentrations. The study subjects were divided into two groups, 28 healthy controls and 38 patients with EGWG. Lower UCL and UCG levels were observed in neonates born to healthy mothers but only in male newborns. In the control group UCG concentrations correlated positively with neonatal birth weight, body length and head circumference. In the control group maternal serum ghrelin levels correlated negatively with neonatal birth weight, body length and head circumference as well as positively with chest circumference. In the EGWG group UCG concentrations correlated negatively with neonatal birth weight and birth body length. UCL correlated positively with birth body length in EGWG group and negatively with head circumference in the control group. In conclusion, EGWG is associated with disturbances in UCL and UCG concentrations. View Full-Text
Keywords: excessive gestational weight gain; neonatal anthropometry; leptin; ghrelin excessive gestational weight gain; neonatal anthropometry; leptin; ghrelin
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Patro-Małysza, J.; Trojnar, M.; Skórzyńska-Dziduszko, K.E.; Kimber-Trojnar, Ż.; Darmochwał-Kolarz, D.; Czuba, M.; Leszczyńska-Gorzelak, B. Leptin and Ghrelin in Excessive Gestational Weight Gain—Association between Mothers and Offspring. Int. J. Mol. Sci. 2019, 20, 2398.

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