Next Article in Journal
The Therapeutic Strategy of HDAC6 Inhibitors in Lymphoproliferative Disease
Next Article in Special Issue
Quantum Modeling: A Bridge between the Pumping and Signaling Functions of Na/K-ATPase
Previous Article in Journal
Large-Scale Functional Analysis of CRP-Mediated Feed-Forward Loops
Previous Article in Special Issue
Na+, K+-ATPase Signaling and Bipolar Disorder
Article Menu
Issue 8 (August) cover image

Export Article

Open AccessReview
Int. J. Mol. Sci. 2018, 19(8), 2336;

Na/K-ATPase Signaling and Cardiac Pre/Postconditioning with Cardiotonic Steroids

Marshall Institute for Interdisciplinary Research, Marshall University, Huntington, West Virginia, WV 25701, USA
Author to whom correspondence should be addressed.
Received: 5 July 2018 / Revised: 5 August 2018 / Accepted: 6 August 2018 / Published: 9 August 2018
Full-Text   |   PDF [933 KB, uploaded 9 August 2018]   |  


The first reports of cardiac Na/K-ATPase signaling, published 20 years ago, have opened several major fields of investigations into the cardioprotective action of low/subinotropic concentrations of cardiotonic steroids (CTS). This review focuses on the protective cardiac Na/K-ATPase-mediated signaling triggered by low concentrations of ouabain and other CTS, in the context of the enduring debate over the use of CTS in the ischemic heart. Indeed, as basic and clinical research continues to support effectiveness and feasibility of conditioning interventions against ischemia/reperfusion injury in acute myocardial infarction (AMI), the mechanistic information available to date suggests that unique features of CTS-based conditioning could be highly suitable, alone /or as a combinatory approach. View Full-Text
Keywords: ouabain; digoxin; ischemia; reperfusion; acute myocardial infarction; kinase ouabain; digoxin; ischemia; reperfusion; acute myocardial infarction; kinase

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Marck, P.V.; Pierre, S.V. Na/K-ATPase Signaling and Cardiac Pre/Postconditioning with Cardiotonic Steroids. Int. J. Mol. Sci. 2018, 19, 2336.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top