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Int. J. Mol. Sci. 2018, 19(8), 2347; https://doi.org/10.3390/ijms19082347

Quantum Modeling: A Bridge between the Pumping and Signaling Functions of Na/K-ATPase

The Joan C. Edwards School of Medicine, Marshall University, 1600 Medical Center Drive, Suite 3408, Huntington, WV 25701, USA
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Received: 11 July 2018 / Revised: 6 August 2018 / Accepted: 7 August 2018 / Published: 9 August 2018
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Abstract

Although the signaling function of Na/K-ATPase has been studied for decades, the chasm between the pumping function and the signaling function of Na/K-ATPase is still an open issue. This article explores the relationship between ion pumping and signaling with attention to the amplification of oxidants through this signaling function. We specifically consider the Na/K-ATPase with respect to its signaling function as a superposition of different states described for its pumping function. We then examine how alterations in the relative amounts of these states could alter signaling through the Src-EGFR-ROS pathway. Using assumptions based on some experimental observations published by our laboratories and others, we develop some predictions regarding cellular oxidant stress. View Full-Text
Keywords: Na/K-ATPase; Markov chain; master equation; Src; oxidant stress; reactive oxygen species; aging Na/K-ATPase; Markov chain; master equation; Src; oxidant stress; reactive oxygen species; aging
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Wang, W.; Shapiro, J.I. Quantum Modeling: A Bridge between the Pumping and Signaling Functions of Na/K-ATPase. Int. J. Mol. Sci. 2018, 19, 2347.

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