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Asteriscus graveolens Extract in Combination with Cisplatin/Etoposide/Doxorubicin Suppresses Lymphoma Cell Growth through Induction of Caspase-3 Dependent Apoptosis

by 1,2 and 1,3,*
1
Dead Sea & Arava Science Center, Sapir 868215, Israel
2
French Assoc. Inst. for Agriculture and Biotechnology of Drylands, Jacob Blaustein Institutes for Desert Research, Ben-Gurion University of the Negev, Midreshet Ben-Gurion 8499000, Israel
3
Regenerative Medicine &Stem Cell Research Center, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(8), 2219; https://doi.org/10.3390/ijms19082219
Received: 5 July 2018 / Revised: 25 July 2018 / Accepted: 28 July 2018 / Published: 30 July 2018
(This article belongs to the Section Bioactives and Nutraceuticals)
Chemotherapy drugs action against cancer is not selective, lead to adverse reactions and drug resistance. Combination therapies have proven more effective in defeating cancers. We hypothesize that plant extract/fraction contains many/several compounds and as such can target multiple pathways as cytotoxic agent and may also have chemo sensitizing activities. We designed a study in which, Asteriscus graveolens (Forssk.) Less (A. graveolens)-derived fraction that contains sesquiterpene lactone asteriscunolide isomers (AS) will be tested in combination with known chemotherapy drugs. Successful combination will permit to reduce chemotherapy drugs concentration and still get the same impact on cancer cells. Sesquiterpene lactone such as asteriscunolide isomers is a naturally occurring compound found in a variety of fruits, vegetables, and medicinal plants with anti-cancer properties. The experiments presented here showed that adding plant fraction containing AS permit reducing the concentration of cisplatin/etoposide/doxorubicin in order to reduce mouse BS-24-1 lymphoma cells (BS-24-1 cells) survival. It involved enhancing the production of Reactive Oxygen Species (ROS), activation of caspase-3 and inhibition of Topoisomerase I activity. Taken together, the results suggest that A. graveolens fraction sensitized BS-24-1 cells to cisplatin/etoposide/doxorubicin through induction of ROS and caspase-3-dependent apoptosis. View Full-Text
Keywords: cisplatin; cancer; ROS; combinatorial therapy; toxicity; cell death; Topoisomerase I; apoptosis cisplatin; cancer; ROS; combinatorial therapy; toxicity; cell death; Topoisomerase I; apoptosis
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MDPI and ACS Style

Tayeh, Z.; Ofir, R. Asteriscus graveolens Extract in Combination with Cisplatin/Etoposide/Doxorubicin Suppresses Lymphoma Cell Growth through Induction of Caspase-3 Dependent Apoptosis. Int. J. Mol. Sci. 2018, 19, 2219. https://doi.org/10.3390/ijms19082219

AMA Style

Tayeh Z, Ofir R. Asteriscus graveolens Extract in Combination with Cisplatin/Etoposide/Doxorubicin Suppresses Lymphoma Cell Growth through Induction of Caspase-3 Dependent Apoptosis. International Journal of Molecular Sciences. 2018; 19(8):2219. https://doi.org/10.3390/ijms19082219

Chicago/Turabian Style

Tayeh, Zainab, and Rivka Ofir. 2018. "Asteriscus graveolens Extract in Combination with Cisplatin/Etoposide/Doxorubicin Suppresses Lymphoma Cell Growth through Induction of Caspase-3 Dependent Apoptosis" International Journal of Molecular Sciences 19, no. 8: 2219. https://doi.org/10.3390/ijms19082219

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