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Int. J. Mol. Sci. 2018, 19(5), 1472; https://doi.org/10.3390/ijms19051472

The Role of Peroxisome Proliferator-Activated Receptors and Their Transcriptional Coactivators Gene Variations in Human Trainability: A Systematic Review

1
Faculty of Physical Education and Sport, Charles University, 162 52 Prague, Czech Republic
2
Department of Theory and Practice of Sport, The Jerzy Kukuczka Academy of Physical Education in Katowice, 40-065 Katowice, Poland
3
Faulty of Physical Education, Gdansk University of Physical Education and Sport, 80-336 Gdansk, Poland
*
Author to whom correspondence should be addressed.
Received: 7 April 2018 / Revised: 11 May 2018 / Accepted: 12 May 2018 / Published: 15 May 2018
(This article belongs to the Special Issue PPARs in Cellular and Whole Body Energy Metabolism)
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Abstract

Background: The peroxisome proliferator-activated receptors (PPARA, PPARG, PPARD) and their transcriptional coactivators’ (PPARGC1A, PPARGC1B) gene polymorphisms have been associated with muscle morphology, oxygen uptake, power output and endurance performance. The purpose of this review is to determine whether the PPARs and/or their coactivators’ polymorphisms can predict the training response to specific training stimuli. Methods: In accordance with the Preferred Reporting Items for Systematic Reviews and Meta Analyses, a literature review has been run for a combination of PPARs and physical activity key words. Results: All ten of the included studies were performed using aerobic training in general, sedentary or elderly populations from 21 to 75 years of age. The non-responders for aerobic training (VO2peak increase, slow muscle fiber increase and low-density lipoprotein decrease) are the carriers of PPARGC1A rs8192678 Ser/Ser. The negative responders for aerobic training (decrease in VO2peak) are carriers of the PPARD rs2267668 G allele. The negative responders for aerobic training (decreased glucose tolerance and insulin response) are subjects with the PPARG rs1801282 Pro/Pro genotype. The best responders to aerobic training are PPARGC1A rs8192678 Gly/Gly, PPARD rs1053049 TT, PPARD rs2267668 AA and PPARG rs1801282 Ala carriers. Conclusions: The human response for aerobic training is significantly influenced by PPARs’ gene polymorphism and their coactivators, where aerobic training can negatively influence glucose metabolism and VO2peak in some genetically-predisposed individuals. View Full-Text
Keywords: human performance; aerobic training; genetic predisposition; anaerobic threshold; muscle fibers; glucose tolerance; insulin response; VO2max; VO2peak; mitochondria activity; cholesterol levels human performance; aerobic training; genetic predisposition; anaerobic threshold; muscle fibers; glucose tolerance; insulin response; VO2max; VO2peak; mitochondria activity; cholesterol levels
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Petr, M.; Stastny, P.; Zajac, A.; Tufano, J.J.; Maciejewska-Skrendo, A. The Role of Peroxisome Proliferator-Activated Receptors and Their Transcriptional Coactivators Gene Variations in Human Trainability: A Systematic Review. Int. J. Mol. Sci. 2018, 19, 1472.

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