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Review

Medicinal Plants Used in the Treatment of Human Immunodeficiency Virus

by
Bahare Salehi
1,2,
Nanjangud V. Anil Kumar
3,
Bilge Şener
4,
Mehdi Sharifi-Rad
5,*,
Mehtap Kılıç
4,
Gail B. Mahady
6,
Sanja Vlaisavljevic
7,
Marcello Iriti
8,*,
Farzad Kobarfard
9,10,
William N. Setzer
11,*,
Seyed Abdulmajid Ayatollahi
9,12,13,
Athar Ata
13 and
Javad Sharifi-Rad
9,13,*
1
Medical Ethics and Law Research Center, Shahid Beheshti University of Medical Sciences, 88777539 Tehran, Iran
2
Student Research Committee, Shahid Beheshti University of Medical Sciences, 22439789 Tehran, Iran
3
Department of Chemistry, Manipal Institute of Technology, Manipal University, Manipal 576104, India
4
Department of Pharmacognosy, Gazi University, Faculty of Pharmacy, 06330 Ankara, Turkey
5
Department of Medical Parasitology, Zabol University of Medical Sciences, 61663-335 Zabol, Iran
6
PAHO/WHO Collaborating Centre for Traditional Medicine, College of Pharmacy, University of Illinois, 833 S. Wood St., Chicago, IL 60612, USA
7
Department of Chemistry, Biochemistry and Environmental Protection, Faculty of Sciences, University of Novi Sad, Trg Dositeja Obradovica 3, 21000 Novi Sad, Serbia
8
Department of Agricultural and Environmental Sciences, Milan State University, 20133 Milan, Italy
9
Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, 11369 Tehran, Iran
10
Department of Medicinal Chemistry, School of Pharmacy, Shahid Beheshti University of Medical Sciences, 11369 Tehran, Iran
11
Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA
12
Department of Pharmacognosy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, 11369 Tehran, Iran
13
Department of Chemistry, Richardson College for the Environmental Science Complex, The University of Winnipeg, Winnipeg, MB R3B 2G3, Canada
 
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Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(5), 1459; https://doi.org/10.3390/ijms19051459
Submission received: 26 March 2018 / Revised: 29 April 2018 / Accepted: 7 May 2018 / Published: 14 May 2018
(This article belongs to the Special Issue Natural Products against Viral Infections)
Versions Notes

Abstract

Since the beginning of the epidemic, human immunodeficiency virus (HIV) has infected around 70 million people worldwide, most of whom reside is sub-Saharan Africa. There have been very promising developments in the treatment of HIV with anti-retroviral drug cocktails. However, drug resistance to anti-HIV drugs is emerging, and many people infected with HIV have adverse reactions or do not have ready access to currently available HIV chemotherapies. Thus, there is a need to discover new anti-HIV agents to supplement our current arsenal of anti-HIV drugs and to provide therapeutic options for populations with limited resources or access to currently efficacious chemotherapies. Plant-derived natural products continue to serve as a reservoir for the discovery of new medicines, including anti-HIV agents. This review presents a survey of plants that have shown anti-HIV activity, both in vitro and in vivo.
Keywords: acquired immune deficiency syndrome; phytochemistry; pharmacognosy; antiviral; drug discovery acquired immune deficiency syndrome; phytochemistry; pharmacognosy; antiviral; drug discovery

Share and Cite

MDPI and ACS Style

Salehi, B.; Kumar, N.V.A.; Şener, B.; Sharifi-Rad, M.; Kılıç, M.; Mahady, G.B.; Vlaisavljevic, S.; Iriti, M.; Kobarfard, F.; Setzer, W.N.; et al. Medicinal Plants Used in the Treatment of Human Immunodeficiency Virus. Int. J. Mol. Sci. 2018, 19, 1459. https://doi.org/10.3390/ijms19051459

AMA Style

Salehi B, Kumar NVA, Şener B, Sharifi-Rad M, Kılıç M, Mahady GB, Vlaisavljevic S, Iriti M, Kobarfard F, Setzer WN, et al. Medicinal Plants Used in the Treatment of Human Immunodeficiency Virus. International Journal of Molecular Sciences. 2018; 19(5):1459. https://doi.org/10.3390/ijms19051459

Chicago/Turabian Style

Salehi, Bahare, Nanjangud V. Anil Kumar, Bilge Şener, Mehdi Sharifi-Rad, Mehtap Kılıç, Gail B. Mahady, Sanja Vlaisavljevic, Marcello Iriti, Farzad Kobarfard, William N. Setzer, and et al. 2018. "Medicinal Plants Used in the Treatment of Human Immunodeficiency Virus" International Journal of Molecular Sciences 19, no. 5: 1459. https://doi.org/10.3390/ijms19051459

APA Style

Salehi, B., Kumar, N. V. A., Şener, B., Sharifi-Rad, M., Kılıç, M., Mahady, G. B., Vlaisavljevic, S., Iriti, M., Kobarfard, F., Setzer, W. N., Ayatollahi, S. A., Ata, A., & Sharifi-Rad, J. (2018). Medicinal Plants Used in the Treatment of Human Immunodeficiency Virus. International Journal of Molecular Sciences, 19(5), 1459. https://doi.org/10.3390/ijms19051459

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