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Article

Neuroprotective Effects of Four Phenylethanoid Glycosides on H2O2-Induced Apoptosis on PC12 Cells via the Nrf2/ARE Pathway

by
Maiquan Li
1,
Tao Xu
1,
Fei Zhou
1,
Mengmeng Wang
1,
Huaxin Song
1,
Xing Xiao
2 and
Baiyi Lu
1,*
1
National Engineering Laboratory of Intelligent Food Technology and Equipment, Key Laboratory for Agro-Products Postharvest Handling of Ministry of Agriculture and Rural Affairs, Key Laboratory for Agro-Products Nutritional Evaluation of Ministry of Agriculture and Rural Affairs, Zhejiang Key Laboratory for Agro-Food Processing, Fuli Institute of Food Science, College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou 310058, China
2
College of The First Clinical Medical, Guangzhou University of Chinese Medicine, Guangzhou 510006, China
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(4), 1135; https://doi.org/10.3390/ijms19041135
Submission received: 12 March 2018 / Revised: 6 April 2018 / Accepted: 7 April 2018 / Published: 10 April 2018
(This article belongs to the Special Issue Plant Natural Products for Human Health)
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Abstract

Nuclear factor erythroid 2-related factor 2 (Nrf2) is a key transcription factor against oxidative stress and neurodegenerative disorders. Phenylethanoid glycosides (PhGs; salidroside, acteoside, isoacteoside, and echinacoside) exhibit antioxidant and neuroprotective bioactivities. This study was performed to investigate the neuroprotective effect and molecular mechanism of PhGs. PhGs pretreatment significantly suppressed H2O2-induced cytotoxicity in PC12 cells by triggering the nuclear translocation of Nrf2 and reversing the downregulated protein expression of heme oxygenase 1 (HO-1), NAD(P)H quinone oxidoreductase 1 (NQO1), glutamate cysteine ligase-catalytic subunit (GCLC), and glutamate-cysteine ligase modifier subunit (GCLM). Nrf2 siRNA or HO-1 inhibitor zinc protoporphyrin (ZnPP) reduced the neuroprotective effect. PhGs showed potential interaction with the Nrf2 binding site in Kelch-like ECH-association protein 1 (Keap1). This result may support the hypothesis that PhGs are activators of Nrf2. We demonstrated the potential binding between PhGs and the Keap1-activated Nrf2/ARE pathway, and that PhGs with more glycosides had enhanced effects.
Keywords: Keap1; Nrf2; Neuroprotective; PC12 cells; PhGs Keap1; Nrf2; Neuroprotective; PC12 cells; PhGs
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MDPI and ACS Style

Li, M.; Xu, T.; Zhou, F.; Wang, M.; Song, H.; Xiao, X.; Lu, B. Neuroprotective Effects of Four Phenylethanoid Glycosides on H2O2-Induced Apoptosis on PC12 Cells via the Nrf2/ARE Pathway. Int. J. Mol. Sci. 2018, 19, 1135. https://doi.org/10.3390/ijms19041135

AMA Style

Li M, Xu T, Zhou F, Wang M, Song H, Xiao X, Lu B. Neuroprotective Effects of Four Phenylethanoid Glycosides on H2O2-Induced Apoptosis on PC12 Cells via the Nrf2/ARE Pathway. International Journal of Molecular Sciences. 2018; 19(4):1135. https://doi.org/10.3390/ijms19041135

Chicago/Turabian Style

Li, Maiquan, Tao Xu, Fei Zhou, Mengmeng Wang, Huaxin Song, Xing Xiao, and Baiyi Lu. 2018. "Neuroprotective Effects of Four Phenylethanoid Glycosides on H2O2-Induced Apoptosis on PC12 Cells via the Nrf2/ARE Pathway" International Journal of Molecular Sciences 19, no. 4: 1135. https://doi.org/10.3390/ijms19041135

APA Style

Li, M., Xu, T., Zhou, F., Wang, M., Song, H., Xiao, X., & Lu, B. (2018). Neuroprotective Effects of Four Phenylethanoid Glycosides on H2O2-Induced Apoptosis on PC12 Cells via the Nrf2/ARE Pathway. International Journal of Molecular Sciences, 19(4), 1135. https://doi.org/10.3390/ijms19041135

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