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DNA Supercoiling, Topoisomerases, and Cohesin: Partners in Regulating Chromatin Architecture?

1
Department of Cell and Molecular Biology, Karolinska Institutet, 17177 Stockholm, Sweden
2
Department of Biosciences and Nutrition, Karolinska Institutet, 141 43 Huddinge, Sweden
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(3), 884; https://doi.org/10.3390/ijms19030884
Received: 8 February 2018 / Revised: 9 March 2018 / Accepted: 13 March 2018 / Published: 16 March 2018
(This article belongs to the Special Issue DNA Topoisomerases)
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Abstract

Although our knowledge of chromatin organization has advanced significantly in recent years, much about the relationships between different features of genome architecture is still unknown. Folding of mammalian genomes into spatial domains is thought to depend on architectural proteins, other DNA-binding proteins, and different forms of RNA. In addition, emerging evidence points towards the possibility that the three-dimensional organisation of the genome is controlled by DNA topology. In this scenario, cohesin, CCCTC-binding factor (CTCF), transcription, DNA supercoiling, and topoisomerases are integrated to dictate different layers of genome organization, and the contribution of all four to gene control is an important direction of future studies. In this perspective, we review recent studies that give new insight on how DNA supercoiling shape chromatin structure. View Full-Text
Keywords: DNA topology; transcription; cohesin; CTCF; genome organization; topoisomerase DNA topology; transcription; cohesin; CTCF; genome organization; topoisomerase
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Björkegren, C.; Baranello, L. DNA Supercoiling, Topoisomerases, and Cohesin: Partners in Regulating Chromatin Architecture? Int. J. Mol. Sci. 2018, 19, 884.

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