Next Article in Journal
Bias-Exchange Metadynamics Simulation of Membrane Permeation of 20 Amino Acids
Next Article in Special Issue
Biochemical Basis of E. coli Topoisomerase I Relaxation Activity Reduction by Nonenzymatic Lysine Acetylation
Previous Article in Journal
HPV Virus Transcriptional Status Assessment in a Case of Sinonasal Carcinoma
Previous Article in Special Issue
Site-Specific Cleavage by Topoisomerase 2: A Mark of the Core Centromere
Open AccessOpinion

DNA Supercoiling, Topoisomerases, and Cohesin: Partners in Regulating Chromatin Architecture?

1
Department of Cell and Molecular Biology, Karolinska Institutet, 17177 Stockholm, Sweden
2
Department of Biosciences and Nutrition, Karolinska Institutet, 141 43 Huddinge, Sweden
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(3), 884; https://doi.org/10.3390/ijms19030884
Received: 8 February 2018 / Revised: 9 March 2018 / Accepted: 13 March 2018 / Published: 16 March 2018
(This article belongs to the Special Issue DNA Topoisomerases)
Although our knowledge of chromatin organization has advanced significantly in recent years, much about the relationships between different features of genome architecture is still unknown. Folding of mammalian genomes into spatial domains is thought to depend on architectural proteins, other DNA-binding proteins, and different forms of RNA. In addition, emerging evidence points towards the possibility that the three-dimensional organisation of the genome is controlled by DNA topology. In this scenario, cohesin, CCCTC-binding factor (CTCF), transcription, DNA supercoiling, and topoisomerases are integrated to dictate different layers of genome organization, and the contribution of all four to gene control is an important direction of future studies. In this perspective, we review recent studies that give new insight on how DNA supercoiling shape chromatin structure. View Full-Text
Keywords: DNA topology; transcription; cohesin; CTCF; genome organization; topoisomerase DNA topology; transcription; cohesin; CTCF; genome organization; topoisomerase
Show Figures

Figure 1

MDPI and ACS Style

Björkegren, C.; Baranello, L. DNA Supercoiling, Topoisomerases, and Cohesin: Partners in Regulating Chromatin Architecture? Int. J. Mol. Sci. 2018, 19, 884. https://doi.org/10.3390/ijms19030884

AMA Style

Björkegren C, Baranello L. DNA Supercoiling, Topoisomerases, and Cohesin: Partners in Regulating Chromatin Architecture? International Journal of Molecular Sciences. 2018; 19(3):884. https://doi.org/10.3390/ijms19030884

Chicago/Turabian Style

Björkegren, Camilla; Baranello, Laura. 2018. "DNA Supercoiling, Topoisomerases, and Cohesin: Partners in Regulating Chromatin Architecture?" Int. J. Mol. Sci. 19, no. 3: 884. https://doi.org/10.3390/ijms19030884

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop