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Open AccessArticle

Association between Plasma HMGB-1 and Silicosis: A Case-Control Study

by Jixuan Ma 1,2, Yun Zhou 1,2, Wei Li 1,2, Lili Xiao 1,2, Meng Yang 1,2, Qiyou Tan 1,2, Yiju Xu 1,2 and Weihong Chen 1,2,*
1
Department of Occupational & Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
2
Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(12), 4043; https://doi.org/10.3390/ijms19124043
Received: 23 November 2018 / Accepted: 10 December 2018 / Published: 14 December 2018
(This article belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
High-mobility group box-1 (HMGB-1) has been associated with fibrotic diseases. However, the role of HMGB-1 in silicosis is still uncertain. In this study, we conducted a case-control study involving 74 patients with silicosis and 107 age/gender-matched healthy controls in China. An Enzyme-linked immunosorbent assay (ELISA) was used to examine the concentrations of plasma HMGB-1 among all subjects. A logistic regression model and receiver operating characteristic curve (ROC) analysis were performed to assess the relationships between HMGB-1 and silicosis. We observed that plasma HMGB-1 concentrations were significantly increased in silicosis patients when compared with healthy controls (p < 0.05). Each 1 ng/mL increase in plasma HMGB-1 was positively associated with increased odds of silicosis, and the odds ratio (OR) (95% confidence interval) was 1.86 (1.52, 2.27). Additionally, compared with subjects with lower HMGB-1 concentrations, increased odds of silicosis were observed in those with higher HMGB-1 concentrations, and the OR was 15.33 (6.70, 35.10). Nonlinear models including a natural cubic spline function of continuous HMGB-1 yielded similar results. In ROC analyses, we found that plasma HMGB-1 >7.419 ng/mL had 81.6% sensitivity and 80.4% specificity for silicosis, and the area under the curve (AUC) was 0.84. Our results demonstrated that elevated plasma HMGB-1 was positivity associated with increased OR of silicosis. View Full-Text
Keywords: biomarker; high mobility group box-1; silicosis biomarker; high mobility group box-1; silicosis
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MDPI and ACS Style

Ma, J.; Zhou, Y.; Li, W.; Xiao, L.; Yang, M.; Tan, Q.; Xu, Y.; Chen, W. Association between Plasma HMGB-1 and Silicosis: A Case-Control Study. Int. J. Mol. Sci. 2018, 19, 4043.

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