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Int. J. Mol. Sci. 2018, 19(12), 3940; https://doi.org/10.3390/ijms19123940

The Multifaceted Roles of Autophagy in Flavivirus-Host Interactions

1,2,3
1
Department of Biochemistry & Molecular Biology and Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan
2
Liver Research Center, Chang Gung Memorial Hospital, Taoyuan 33305, Taiwan
3
Division of Allergy, Immunology and Rheumatology, Chang Gung Memorial Hospital, Taoyuan 33305, Taiwan
Received: 13 November 2018 / Revised: 5 December 2018 / Accepted: 5 December 2018 / Published: 7 December 2018
(This article belongs to the Special Issue Hepatitis Virus Infection and Molecular Research 2018)
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Abstract

Autophagy is an evolutionarily conserved cellular process in which intracellular components are eliminated via lysosomal degradation to supply nutrients for organelle biogenesis and metabolic homeostasis. Flavivirus infections underlie multiple human diseases and thus exert an immense burden on public health worldwide. Mounting evidence indicates that host autophagy is subverted to modulate the life cycles of flaviviruses, such as hepatitis C virus, dengue virus, Japanese encephalitis virus, West Nile virus and Zika virus. The diverse interplay between autophagy and flavivirus infection not only regulates viral growth in host cells but also counteracts host stress responses induced by viral infection. In this review, we summarize the current knowledge on the role of autophagy in the flavivirus life cycle. We also discuss the impacts of virus-induced autophagy on the pathogeneses of flavivirus-associated diseases and the potential use of autophagy as a therapeutic target for curing flavivirus infections and related human diseases. View Full-Text
Keywords: Flaviviridae; Autophagy; selective autophagy; Hepatitis C virus; Dengue virus; Japanese encephalitis virus; West Nile virus; Zika virus Flaviviridae; Autophagy; selective autophagy; Hepatitis C virus; Dengue virus; Japanese encephalitis virus; West Nile virus; Zika virus
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Ke, P.-Y. The Multifaceted Roles of Autophagy in Flavivirus-Host Interactions. Int. J. Mol. Sci. 2018, 19, 3940.

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