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Int. J. Mol. Sci. 2018, 19(12), 3935; https://doi.org/10.3390/ijms19123935

Anticancer Action and Mechanism of Ergosterol Peroxide from Paecilomyces cicadae Fermentation Broth

1
School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China
2
School of Life Science, East China Normal University, Shanghai 200241, China
*
Author to whom correspondence should be addressed.
Received: 24 October 2018 / Revised: 26 November 2018 / Accepted: 27 November 2018 / Published: 7 December 2018
(This article belongs to the Section Bioactives and Nutraceuticals)
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Abstract

Isaria cicadae, a medicinal food fungus, is a fruit from Paecilomyces cicadae. In this study, we purified ergosterol peroxide (EP) from the fermentation broth of P. cicadae and investigated its effects on renal cell carcinoma (RCC) cells, in vitro. EP was purified from P. cicadae fermentation broth. The human RCC cell line 786-0 was used to analyze the anticancer mechanism of EP and inhibit its effect on cancer cell proliferation, in vitro. EP with a validated structure showed a yield rate of 20.1 mg/L and a purity of 96%. EP significantly inhibited RCC cell growth and clone formation in vitro. In addition, EP suppressed the migration and invasion, triggered the apoptosis, and modulated the cell cycle of RCC cells, in a dose-dependent manner. It also downregulated β-catenin expression. EP could be routinely produced through P. cicadae. It fights RCC cells in vitro through multiple mechanisms, including suppressing cell growth, colonization, migration, and invasion, arresting the cell cycle, attenuating β-catenin pathways, and triggering apoptosis. View Full-Text
Keywords: ergosterol peroxide; renal cell carcinoma; apoptosis; cell cycle; Paecilomyces cicadae ergosterol peroxide; renal cell carcinoma; apoptosis; cell cycle; Paecilomyces cicadae
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He, L.; Shi, W.; Liu, X.; Zhao, X.; Zhang, Z. Anticancer Action and Mechanism of Ergosterol Peroxide from Paecilomyces cicadae Fermentation Broth. Int. J. Mol. Sci. 2018, 19, 3935.

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