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Int. J. Mol. Sci. 2018, 19(12), 3929; https://doi.org/10.3390/ijms19123929

The Power of Fish Models to Elucidate Skin Cancer Pathogenesis and Impact the Discovery of New Therapeutic Opportunities

1
Department of Chemistry, Chung Yuan Christian University, Chung-Li 32023, Taiwan
2
Department of Bioscience Technology, Chung Yuan Christian University, Chung-Li 32023, Taiwan
3
Department of Chemistry, Chinese Culture University, Taipei 11114, Taiwan
4
Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250103, China
5
Taiwan Center for Biomedical Technology, Chung Yuan Christian University, Chung-Li 32023, Taiwan
6
Center for Nanotechnology, Chung Yuan Christian University, Chung-Li 32023, Taiwan
*
Authors to whom correspondence should be addressed.
Received: 15 November 2018 / Revised: 30 November 2018 / Accepted: 5 December 2018 / Published: 7 December 2018
(This article belongs to the Special Issue Molecular Aspects of Cutaneous Squamous Cell Carcinoma)
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Abstract

Animal models play important roles in investigating the pathobiology of cancer, identifying relevant pathways, and developing novel therapeutic tools. Despite rapid progress in the understanding of disease mechanisms and technological advancement in drug discovery, negative trial outcomes are the most frequent incidences during a Phase III trial. Skin cancer is a potential life-threatening disease in humans and might be medically futile when tumors metastasize. This explains the low success rate of melanoma therapy amongst other malignancies. In the past decades, a number of skin cancer models in fish that showed a parallel development to the disease in humans have provided important insights into the fundamental biology of skin cancer and future treatment methods. With the diversity and breadth of advanced molecular genetic tools available in fish biology, fish skin cancer models will continue to be refined and expanded to keep pace with the rapid development of skin cancer research. This review begins with a brief introduction of molecular characteristics of skin cancers, followed by an overview of teleost models that have been used in the last decades in melanoma research. Next, we will detail the importance of the zebrafish (Danio rerio) animal model and other emerging fish models including platyfish (Xiphophorus sp.), and medaka (Oryzias latipes) in future cutaneous malignancy studies. The last part of this review provides the recent development and genome editing applications of skin cancer models in zebrafish and the progress in small molecule screening. View Full-Text
Keywords: skin cancer models; zebrafish; medaka; molecule screening skin cancer models; zebrafish; medaka; molecule screening
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Sarasamma, S.; Lai, Y.-H.; Liang, S.-T.; Liu, K.; Hsiao, C.-D. The Power of Fish Models to Elucidate Skin Cancer Pathogenesis and Impact the Discovery of New Therapeutic Opportunities. Int. J. Mol. Sci. 2018, 19, 3929.

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