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Int. J. Mol. Sci. 2018, 19(12), 3928; https://doi.org/10.3390/ijms19123928

TGFβ Superfamily Members as Regulators of B Cell Development and Function—Implications for Autoimmunity

1
Departamento de Biología Molecular-IDIVAL Universidad de Cantabria, Santander 39011, Spain
2
Instituto de Biomedicina y Biotecnología de Cantabria, Consejo Superior de Investigaciones Científicas-Universidad de Cantabria, Santander 39011, Spain
*
Authors to whom correspondence should be addressed.
Received: 16 November 2018 / Revised: 4 December 2018 / Accepted: 5 December 2018 / Published: 7 December 2018
(This article belongs to the Special Issue B Cells and Immunological Tolerance)
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Abstract

The TGFβ superfamily is composed of more than 33 growth and differentiation factors, including TGFβ1, β2, β3, BMPs, GDFs, nodal-related proteins, and activins. These members usually exert pleiotropic actions on several tissues and control multiple cellular processes, such as cell growth, cell survival, cell migration, cell fate specification, and differentiation, both during embryonic development and postnatal life. Although the effects of these factors on immune responses were elucidated long ago, most studies have been focused on the actions of TGFβs on T cells, as major regulators of adaptive immunity. In this review, we discuss new findings about the involvement of TGFβ superfamily members in the control of B cell development and function. Moreover, the potential contribution of TGFβ signaling to control B cell-mediated autoimmune diseases and its utility in the design of new therapies are also discussed. View Full-Text
Keywords: TGFβ superfamily; TGFβ signaling; B cell; immune homeostasis; tolerance; autoimmunity TGFβ superfamily; TGFβ signaling; B cell; immune homeostasis; tolerance; autoimmunity
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Tamayo, E.; Alvarez, P.; Merino, R. TGFβ Superfamily Members as Regulators of B Cell Development and Function—Implications for Autoimmunity. Int. J. Mol. Sci. 2018, 19, 3928.

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