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Developmental Expression and Functions of the Small Heat Shock Proteins in Drosophila

1
GReD, INSERM U1103, CNRS UMR6293, University of Clermont Auvergne, 28, Place Henri Dunant, 63000 Clermont-Ferrand, France
2
Department of Animal Developmental Biology, Institute of Experimental Biology, University of Wroclaw, Wroclaw, Sienkiewicza 21, 50-335 Wroclaw, Poland
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(11), 3441; https://doi.org/10.3390/ijms19113441
Received: 29 September 2018 / Revised: 29 October 2018 / Accepted: 30 October 2018 / Published: 2 November 2018
(This article belongs to the Special Issue Molecular Chaperones)
Heat shock proteins (Hsps) form a large family of evolutionarily conserved molecular chaperones that help balance protein folding and protect cells from various stress conditions. However, there is growing evidence that Hsps may also play an active role in developmental processes. Here, we take the example of developmental expression and function of one class of Hsps characterized by low molecular weight, the small Hsps (sHsps). We discuss recent reports and genome-wide datasets that support vital sHsps functions in the developing nervous system, reproductive system, and muscles. This tissue- and time-specific sHsp expression is developmentally regulated, so that the enhancer sequence of an sHsp gene expressed in developing muscle, in addition to stress-inducible elements, also carries binding sites for myogenic regulatory factors. One possible reason for sHsp genes to switch on during development and in non-stress conditions is to protect vital developing organs from environmental insults. View Full-Text
Keywords: sHsp; Drosophila; embryonic development; muscle; nervous system; reproductive system sHsp; Drosophila; embryonic development; muscle; nervous system; reproductive system
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MDPI and ACS Style

Jagla, T.; Dubińska-Magiera, M.; Poovathumkadavil, P.; Daczewska, M.; Jagla, K. Developmental Expression and Functions of the Small Heat Shock Proteins in Drosophila. Int. J. Mol. Sci. 2018, 19, 3441. https://doi.org/10.3390/ijms19113441

AMA Style

Jagla T, Dubińska-Magiera M, Poovathumkadavil P, Daczewska M, Jagla K. Developmental Expression and Functions of the Small Heat Shock Proteins in Drosophila. International Journal of Molecular Sciences. 2018; 19(11):3441. https://doi.org/10.3390/ijms19113441

Chicago/Turabian Style

Jagla, Teresa; Dubińska-Magiera, Magda; Poovathumkadavil, Preethi; Daczewska, Małgorzata; Jagla, Krzysztof. 2018. "Developmental Expression and Functions of the Small Heat Shock Proteins in Drosophila" Int. J. Mol. Sci. 19, no. 11: 3441. https://doi.org/10.3390/ijms19113441

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