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Antiproliferative Effects of Alkaloid Evodiamine and Its Derivatives

1,†, 1,†, 2, 3, 4, 5, 1 and 1,6,*
1
Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, and School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China
2
School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China
3
Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang 222001, China
4
School of Public Health, Qingdao University, Qingdao 266021, China
5
Faculty of Functional Food and Wine, Shenyang Pharmaceutical University, Shenyang 110016, China
6
Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2018, 19(11), 3403; https://doi.org/10.3390/ijms19113403
Received: 5 October 2018 / Revised: 20 October 2018 / Accepted: 24 October 2018 / Published: 30 October 2018
(This article belongs to the Special Issue Natural and Semi-Synthetic Small Molecules in Drug Discovery)
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PDF [5176 KB, uploaded 30 October 2018]
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Abstract

Alkaloids, a category of natural products with ring structures and nitrogen atoms, include most U.S. Food and Drug Administration approved plant derived anti-cancer agents. Evodiamine is an alkaloid with attractive multitargeting antiproliferative activity. Its high content in the natural source ensures its adequate supply on the market and guarantees further medicinal study. To the best of our knowledge, there is no systematic review about the antiproliferative effects of evodiamine derivatives. Therefore, in this article the review of the antiproliferative activities of evodiamine will be updated. More importantly, the antiproliferative activities of structurally modified new analogues of evodiamine will be summarized for the first time. View Full-Text
Keywords: evodiamine; alkaloid; antiproliferative effect; structural modification evodiamine; alkaloid; antiproliferative effect; structural modification
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Hu, X.; Li, D.; Chu, C.; Li, X.; Wang, X.; Jia, Y.; Hua, H.; Xu, F. Antiproliferative Effects of Alkaloid Evodiamine and Its Derivatives. Int. J. Mol. Sci. 2018, 19, 3403.

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