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Open AccessReview

Molecular Biomarkers for Gestational Diabetes Mellitus

1
Biomedical Research and Innovation Platform, South African Medical Research Council, P.O. Box 19070, Tygerberg, Cape Town 7505, South Africa
2
Department of Obstetrics and Gynecology, University of Pretoria, Private Bag X169, Pretoria 0001, South Africa
3
Division of Medical Physiology, Faculty of Health Sciences, Stellenbosch University, P.O. Box 19063, Tygerberg, Cape Town 7505, South Africa
4
Department of Internal Medicine, Faculty of Health Sciences, University of Pretoria, Private Bag X169, Pretoria 0001, South Africa
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(10), 2926; https://doi.org/10.3390/ijms19102926
Received: 31 August 2018 / Revised: 21 September 2018 / Accepted: 22 September 2018 / Published: 26 September 2018
(This article belongs to the Special Issue Risk Factors and Molecular Mechanisms of Gestational Diabetes)
Gestational diabetes mellitus (GDM) is a growing public health problem worldwide. The condition is associated with perinatal complications and an increased risk for future metabolic disease in both mothers and their offspring. In recent years, molecular biomarkers received considerable interest as screening tools for GDM. The purpose of this review is to provide an overview of the current status of single-nucleotide polymorphisms (SNPs), DNA methylation, and microRNAs as biomarkers for GDM. PubMed, Scopus, and Web of Science were searched for articles published between January 1990 and August 2018. The search terms included “gestational diabetes mellitus”, “blood”, “single-nucleotide polymorphism (SNP)”, “DNA methylation”, and “microRNAs”, including corresponding synonyms and associated terms for each word. This review updates current knowledge of the candidacy of these molecular biomarkers for GDM with recommendations for future research avenues. View Full-Text
Keywords: molecular biomarkers; gestational diabetes mellitus; DNA methylation; microRNAs; single-nucleotide polymorphism; genetic and epigenetic markers molecular biomarkers; gestational diabetes mellitus; DNA methylation; microRNAs; single-nucleotide polymorphism; genetic and epigenetic markers
MDPI and ACS Style

Dias, S.; Pheiffer, C.; Abrahams, Y.; Rheeder, P.; Adam, S. Molecular Biomarkers for Gestational Diabetes Mellitus. Int. J. Mol. Sci. 2018, 19, 2926.

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