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Specialized Pro-Resolving Lipid Mediators in Cystic Fibrosis

INSERM, U1151, Institut Necker Enfants Malades, 75993 Paris, France
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(10), 2865;
Received: 31 August 2018 / Revised: 14 September 2018 / Accepted: 15 September 2018 / Published: 21 September 2018
(This article belongs to the Special Issue Bioactive Lipids and Lipidomics 2018)
In cystic fibrosis (CF), impaired airway surface hydration (ASL) and mucociliary clearance that promote chronic bacterial colonization, persistent inflammation, and progressive structural damage to the airway wall architecture are typically explained by ion transport abnormalities related to the mutation of the gene coding for the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) channel. However, the progressive and unrelenting inflammation of the CF airway begins early in life, becomes persistent, and is excessive relative to the bacterial burden. Intrinsic abnormalities of the inflammatory response in cystic fibrosis have been suggested but the mechanisms involved remain poorly understood. This review aims to give an overview of the recent advances in the understanding of the defective resolution of inflammation in CF including the abnormal production of specialized pro-resolving lipid mediators (lipoxin and resolvin) and their impact on the pathogenesis of the CF airway disease. View Full-Text
Keywords: resolvin; lipoxin; cystic fibrosis resolvin; lipoxin; cystic fibrosis
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MDPI and ACS Style

Philippe, R.; Urbach, V. Specialized Pro-Resolving Lipid Mediators in Cystic Fibrosis. Int. J. Mol. Sci. 2018, 19, 2865.

AMA Style

Philippe R, Urbach V. Specialized Pro-Resolving Lipid Mediators in Cystic Fibrosis. International Journal of Molecular Sciences. 2018; 19(10):2865.

Chicago/Turabian Style

Philippe, Réginald, and Valerie Urbach. 2018. "Specialized Pro-Resolving Lipid Mediators in Cystic Fibrosis" International Journal of Molecular Sciences 19, no. 10: 2865.

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