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How Sweet Are Our Gut Beneficial Bacteria? A Focus on Protein Glycosylation in Lactobacillus

Quadram Institute Bioscience, The Gut Health and Food Safety Institute Strategic Programme, Norwich Research Park, Norwich NR4 7UA, UK
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Int. J. Mol. Sci. 2018, 19(1), 136; https://doi.org/10.3390/ijms19010136
Received: 22 November 2017 / Revised: 22 December 2017 / Accepted: 27 December 2017 / Published: 3 January 2018
(This article belongs to the Special Issue Glycosylation and Glycoproteins 2017)
Protein glycosylation is emerging as an important feature in bacteria. Protein glycosylation systems have been reported and studied in many pathogenic bacteria, revealing an important diversity of glycan structures and pathways within and between bacterial species. These systems play key roles in virulence and pathogenicity. More recently, a large number of bacterial proteins have been found to be glycosylated in gut commensal bacteria. We present an overview of bacterial protein glycosylation systems (O- and N-glycosylation) in bacteria, with a focus on glycoproteins from gut commensal bacteria, particularly Lactobacilli. These emerging studies underscore the importance of bacterial protein glycosylation in the interaction of the gut microbiota with the host. View Full-Text
Keywords: protein glycosylation; gut commensal bacteria; Lactobacillus; glycoproteins; adhesins; lectins; O-glycosylation; N-glycosylation; probiotics protein glycosylation; gut commensal bacteria; Lactobacillus; glycoproteins; adhesins; lectins; O-glycosylation; N-glycosylation; probiotics
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MDPI and ACS Style

Latousakis, D.; Juge, N. How Sweet Are Our Gut Beneficial Bacteria? A Focus on Protein Glycosylation in Lactobacillus. Int. J. Mol. Sci. 2018, 19, 136.

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