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Int. J. Mol. Sci. 2017, 18(9), 1875;

Patient-Derived Orthotopic Xenograft (PDOX) Models of Melanoma

AntiCancer Inc., 7917 Ostrow Street, San Diego, CA 92111, USA
Department of Surgery, University of California, San Diego, CA 92103-8220, USA
This article is dedicated to the memory of Abdool R. Moossa and Sun Lee.
Received: 5 August 2017 / Revised: 16 August 2017 / Accepted: 23 August 2017 / Published: 31 August 2017
(This article belongs to the Special Issue Animal Models of Melanoma)
Full-Text   |   PDF [6429 KB, uploaded 31 August 2017]   |  


Metastatic melanoma is a recalcitrant tumor. Although “targeted” and immune therapies have been highly touted, only relatively few patients have had durable responses. To overcome this problem, our laboratory has established the melanoma patient-derived orthotopic xenograft (PDOX) model with the use of surgical orthotopic implantation (SOI). Promising results have been obtained with regard to identifying effective approved agents and experimental therapeutics, as well as combinations of the two using the melanoma PDOX model. View Full-Text
Keywords: melanoma; patient-derived orthotopic xenografts; PDOX; targeted therapy; personalized therapy melanoma; patient-derived orthotopic xenografts; PDOX; targeted therapy; personalized therapy

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Hoffman, R.M. Patient-Derived Orthotopic Xenograft (PDOX) Models of Melanoma. Int. J. Mol. Sci. 2017, 18, 1875.

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