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Case Report

Pigmented Epithelioid Melanocytoma (PEM)/Animal Type Melanoma (ATM): Quest for an Origin. Report of One Unusual Case Indicating Follicular Origin and Another Arising in an Intradermal Nevus

1
Departments of Dermatology and Pathology, University of Alabama at Birmingham, Birmingham, AL 35201, USA
2
Department of Dermatopathology, Albany Medical College, Albany, NY 12201, USA
3
Department of Biochemistry and Molecular Biology, Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA
4
Center for Cancer Research, National Cancer Institute, Bethesda, MD 21201, USA
5
Veterans Affairs Medical Center, Birmingham, AL 35201, USA
*
Author to whom correspondence should be addressed.
Abstract Presented during the Poster Session at the American Society of Dermatopathology (ASDP) 2015 Annual Meeting, October, 2015, San Francisco, CA 94101, USA.
Int. J. Mol. Sci. 2017, 18(8), 1769; https://doi.org/10.3390/ijms18081769
Received: 25 July 2017 / Revised: 8 August 2017 / Accepted: 10 August 2017 / Published: 15 August 2017
(This article belongs to the Special Issue Animal Models of Melanoma)
Pigmented epithelioid melanocytoma (PEM) is a tumor encompassing epithelioid blue nevus of Carney complex (EBN of CNC) and was previously termed animal-type melanoma. Histologically PEMs are heavily pigmented spindled and epithelioid dermal melanocytic tumors with infiltrative borders, however, their origin remains unclear. Stem cells for the epidermis and hair follicle are located in the bulge area of the hair follicle with the potential to differentiate into multiple lineages. Multiple cutaneous carcinomas, including follicular cutaneous squamous cell carcinoma (FSCC), are thought to arise from stem cells in the follicular bulge. We present two cases of PEM/ATM in a 63 year-old male on the scalp with follicular origin and a 72 year-old female on the upper back arising in an intradermal nevus. Biopsy of both cases revealed a proliferation of heavily pigmented dermal nests of melanocytes with atypia. The Case 1 tumor was in continuation with the outer root sheath of the hair follicle in the bulge region. Case 2 arose in an intradermal melanocytic nevus. Rare mitotic figures, including atypical mitotic figures, were identified in both cases. We present two cases of PEM, with histologic evidence suggesting two origins: one from the follicular bulb and one from an intradermal nevus. View Full-Text
Keywords: melanocytes; melanoma; hair follicle; hair follicle stem cell; melanin pigment melanocytes; melanoma; hair follicle; hair follicle stem cell; melanin pigment
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MDPI and ACS Style

Tarasen, A.; Carlson, J.A.; Leonard, M.K.; Merlino, G.; Kaetzel, D.; Slominski, A.T. Pigmented Epithelioid Melanocytoma (PEM)/Animal Type Melanoma (ATM): Quest for an Origin. Report of One Unusual Case Indicating Follicular Origin and Another Arising in an Intradermal Nevus. Int. J. Mol. Sci. 2017, 18, 1769. https://doi.org/10.3390/ijms18081769

AMA Style

Tarasen A, Carlson JA, Leonard MK, Merlino G, Kaetzel D, Slominski AT. Pigmented Epithelioid Melanocytoma (PEM)/Animal Type Melanoma (ATM): Quest for an Origin. Report of One Unusual Case Indicating Follicular Origin and Another Arising in an Intradermal Nevus. International Journal of Molecular Sciences. 2017; 18(8):1769. https://doi.org/10.3390/ijms18081769

Chicago/Turabian Style

Tarasen, Ashley, J. A. Carlson, M. K. Leonard, Glenn Merlino, David Kaetzel, and Andrzej T. Slominski 2017. "Pigmented Epithelioid Melanocytoma (PEM)/Animal Type Melanoma (ATM): Quest for an Origin. Report of One Unusual Case Indicating Follicular Origin and Another Arising in an Intradermal Nevus" International Journal of Molecular Sciences 18, no. 8: 1769. https://doi.org/10.3390/ijms18081769

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